Veraphenol
Veraphenol Basic information
- Product Name:
- Veraphenol
- Synonyms:
-
- 2-(3,5-Dihydroxyphenyl)benzofuran-6-ol
- Moracin M
- Veraphenol
- 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzofuran
- 6,3',5'-Trihydroxy-2-phenylbenzofuran
- 5-(6-hydroxy-1-benzofuran-2-yl)benzene-1,3-diol
- 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-
- 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol
- CAS:
- 56317-21-6
- MF:
- C14H10O4
- MW:
- 242.23
- Mol File:
- 56317-21-6.mol
Veraphenol Chemical Properties
- Melting point:
- 271-273℃
- Boiling point:
- 369.3±22.0 °C(Predicted)
- Density
- 1.451±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: 16.67 mg/mL (68.82 mM)
- form
- Powder
- pka
- 9.05±0.40(Predicted)
- color
- Off-white to light yellow
Veraphenol Usage And Synthesis
Uses
Moracin M is a tyrosinase inhibitory polyphenols from roots of Morus Alba. It also showed hypoglycemic effect by reducing glucose levels and lipid peroxidation and increasing insulin levels in rats with streptozotocin-induced diabetes mellitus.
Definition
ChEBI: Moracin M is a member of benzofurans.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 2645, 1987 DOI: 10.1016/S0040-4039(00)96171-9
in vivo
Moracin M (20, 60 mg/kg, Oral gavage) reduces inflammatory response in LPS (HY-D1056) -induced acute lung injury (ALI) mouse models, decreases the total number of infiltrated cells in bronchoalveolar lavage (BAL) fluid, and significantly reduces the number of neutrophils, macrophages and dendritic cells[2].
Moracin M (20, 60 mg/kg, Oral gavage) alleviates pathological changes in lung tissue in ALI mouse models, including reduces alveolar wall thickness, increases alveolar space, and reduces inflammatory cell infiltration in lung tissue[2].
Moracin M (20, 60 mg/kg, Oral gavage) significantly inhibits NF-κB activation in the lungs in a mouse model of ALI[2].
| Animal Model: | LPS-induced acute lung injury (ALI) mouse models[2] |
| Dosage: | LPS (HY-D1056) 2 mg/kg; LPS 2 mg/kg+ Moracin M 20 mg/kg, 60 mg/kg; LPS 2 mg/kg+ Dexamethasone (HY-14648) 30 mg/kg. (n=13) |
| Administration: | Oral gavage |
| Result: | Reduced the inflammatory response in ALI mouse models and reduced the total number of cells infiltrated in bronchoalveolar lavage (BAL) fluid. The number of neutrophils, macrophages and dendritic cells was significantly decreased. Reduced the thickness of alveolar wall, increasing alveolar space, and reduced the infiltration of inflammatory cells in lung tissue. |
target
PDE
IC 50
PDE4D2: 2.9 μM (IC50); PDE4B2: 4.5 μM (IC50); PDE5A1: >40 μM (IC50); PDE9A2: >100 μM (IC50)
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