1-Ethenyl-4-methoxy-9H-pyrido[3,4-b]indol-8-ol Chemical Properties

Boiling point:

528.2±45.0 °C(Predicted)

Density 

1.352±0.06 g/cm3(Predicted)

pka

9.38±0.30(Predicted)

1-Ethenyl-4-methoxy-9H-pyrido[3,4-b]indol-8-ol Usage And Synthesis

Uses

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1[1][2].

References

[1] Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. DOI:10.3390/ijms23116103
[2] Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435. DOI:10.1159/000481874

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