CALYCULIN A
CALYCULIN A Basic information
- Product Name:
- CALYCULIN A
- Synonyms:
-
- C05370
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
- CALYCULIN A
- CALYCULIN A, DISCODERMIA CALYX
- calyculin A from discodermia calyx
- CALYCULIN A FROM DISCODERMIA CALYX, 10 U G
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
- N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o
- CAS:
- 101932-71-2
- MF:
- C50H81N4O15P
- MW:
- 1009.17
- Product Categories:
-
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Biology
- Protein phosphatase-1, Catalytic SubunitCancer Research
- Tumor Promotors
- Cell Signaling and Neuroscience
- P to
- Serine/Threonine Phosphatase Substrates
- Phosphatase InhibitorsSerine/Threonine Kinase Biology
- Protein Phosphatase 1 (PP1)Enzyme Inhibitors by Enzyme
- Serine/Threonine Phosphatase Inhibitors
- Tumor Growth Regulation
- Inhibitor
- Mol File:
- 101932-71-2.mol
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CALYCULIN A Chemical Properties
- Melting point:
- 247-249°
- alpha
- D -60° (c = 0.1 in ethanol)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- solid
- pka
- 1.81±0.10(Predicted)
- color
- white
- Water Solubility
- Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water.
- Merck
- 13,1731
- BRN
- 4903216
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Safety Information
- Hazard Codes
- T
- Risk Statements
- 23/24/25-38
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 3462 6.1/PG 3
- WGK Germany
- 3
- F
- 8-10
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 2934999090
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CALYCULIN A Usage And Synthesis
Uses
Calyculin A is a PP1 and PP2A-C inhibitor and tumor inducer.
Uses
Calyculin A from Discodermia calyx has been used:
- as an inhibitor of serine-threonine protein phosphatase 2A
- as an inhibitor of cyclin D1 phosphatase in human breast cancer cells
- as an inhibitor of protein phosphatase 2A (PP2A) and PP1 in mouse melanoma cell lines B16-F0 cells
Uses
Inhibitor of phosphatases 1 and 2a.
General Description
Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da.
Biological Activity
Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
Biochem/physiol Actions
Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor.
storage
Store at -20°C
CALYCULIN ASupplier
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