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NODULARIN

Basic information Safety Supplier Related

NODULARIN Basic information

Product Name:
NODULARIN
Synonyms:
  • tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
  • yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)
  • NODULARIN
  • 1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
  • Nodularin, Nodularia spumigena
  • 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
  • Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
  • Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
CAS:
118399-22-7
MF:
C41H60N8O10
MW:
824.96
EINECS:
621-437-9
Product Categories:
  • Natural Products
Mol File:
118399-22-7.mol
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NODULARIN Chemical Properties

Density 
1.29±0.1 g/cm3(Predicted)
Flash point:
11℃
storage temp. 
−20°C
solubility 
methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
form 
Dry residue containing traces of monobasic potassium phosphate.
pka
3.39±0.70(Predicted)
IARC
3 (Vol. 94) 2010
EPA Substance Registry System
Nodularin (118399-22-7)
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Safety Information

Hazard Codes 
T,F,T+
Risk Statements 
23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
Safety Statements 
36/37-45-16-7-36/37/39-26
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
GU2294250
Hazardous Substances Data
118399-22-7(Hazardous Substances Data)
Toxicity
mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.

MSDS

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NODULARIN Usage And Synthesis

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Uses

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Definition

Toxin produced by blue green algae.

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