NODULARIN
NODULARIN Basic information
- Product Name:
- NODULARIN
- Synonyms:
-
- tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
- yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)
- NODULARIN
- 1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
- Nodularin, Nodularia spumigena
- 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
- Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
- Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
- CAS:
- 118399-22-7
- MF:
- C41H60N8O10
- MW:
- 824.96
- EINECS:
- 621-437-9
- Product Categories:
-
- Natural Products
- Mol File:
- 118399-22-7.mol
NODULARIN Chemical Properties
- Density
- 1.29±0.1 g/cm3(Predicted)
- Flash point:
- 11℃
- storage temp.
- −20°C
- solubility
- methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.
- form
- Dry residue containing traces of monobasic potassium phosphate.
- pka
- 3.39±0.70(Predicted)
- IARC
- 3 (Vol. 94) 2010
- EPA Substance Registry System
- Nodularin (118399-22-7)
Safety Information
- Hazard Codes
- T,F,T+
- Risk Statements
- 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28
- Safety Statements
- 36/37-45-16-7-36/37/39-26
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- GU2294250
- Hazardous Substances Data
- 118399-22-7(Hazardous Substances Data)
- Toxicity
- mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993.
MSDS
- Language:English Provider:SigmaAldrich
NODULARIN Usage And Synthesis
Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Uses
Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
Definition
Toxin produced by blue green algae.
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NODULARIN(118399-22-7)Related Product Information
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- PHENYLSELENOL
- METHYL ISOCYANOACETATE
- 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
- Tosylmethyl isocyanide
- SALCOMINE
- N-BUTYLISOCYANIDE
- Cupric acetylacetonate
- Benzyl isocyanide
- Aluminum acetylacetonate
- 2,4-PENTANEDIONE, SILVER DERIVATIVE
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
- Ferric acetylacetonate
- DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
- TERT-BUTYL ISOCYANIDE
- COBALT(II) ACETYLACETONATE
- TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
- Ethyl isocyanoacetate