2-Amino-6-fluorobenzonitrile Chemical Properties

Melting point:

125-128 °C (lit.)

Boiling point:

275.8±25.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Chloroform

form 

Solid

pka

0.80±0.10(Predicted)

color 

Pale Yellow

BRN 

3588945

CAS DataBase Reference

77326-36-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T,Xn

Risk Statements 

36-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39-22

RIDADR 

3439

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269090

MSDS

• Language:English Provider:2-Amino-6-fluorobenzonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Amino-6-fluorobenzonitrile Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-fluorobenzonitrile, a medicinal chemistry intermediate, has been employed for the preparation of tacrine-related compounds. It may be used for the synthesis of antifolate and antibacterial quinazoline derivatives.
It may be used for the synthesis bis(4-oxoquinazolin-2-yl)pyridine and fluoro-containing quinazolin-4(1H)-ones. It may be employed for the synthesis of the following novel huprines:

• 12-amino-3-chloro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
• 9-allyl-12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride
• 12-amino-1-fluoro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride
• 9-allyl-12-amino-1-fluoro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride

General Description

2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.

2-Amino-6-fluorobenzonitrile(77326-36-4)Related Product Information

• ALTRENOGEST
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• Diaminomaleonitrile
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• 2-DIMETHYLAMINO-6-FLUOROBENZONITRILE
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• N-(2-CYANO-3-FLUOROPHENYL)PYRROLE
• N1-(2-CYANO-3-FLUOROPHENYL)-2-CHLOROACETAMIDE