2-Amino-5-fluorobenzonitrile Chemical Properties

Melting point:

92-96 °C (lit.)

Boiling point:

138 °C/15 mmHg (lit.)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder

pka

1.87±0.10(Predicted)

color 

Faint yellow to faint brown

CAS DataBase Reference

61272-77-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22

Safety Statements 

22-24/25

RIDADR 

3439

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2926907090

MSDS

• Language:English Provider:SigmaAldrich

2-Amino-5-fluorobenzonitrile Usage And Synthesis

Uses

2-Amino-5-fluorobenzonitrile is a key intermediate.

Chemical Properties

white to light yellow crystal powder

Synthesis

GENERAL METHODS: Azide-based compounds (1 mmol) were added to an aqueous solution (5 mL) containing freshly prepared Fe(0) nanoparticles (3 mmol) at room temperature and under argon atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was extracted with ethyl acetate (3 × 10 mL), ensuring that all Fe-containing material was retained around the stir bar. Subsequently, the solvent in the organic phase was evaporated and the crude product was purified by short column chromatography. The final product was structurally confirmed by infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR) and carbon nuclear magnetic resonance (13C NMR) data.

References

[1] Tetrahedron Letters, 2017, vol. 58, # 35, p. 3457 - 3460

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