3-METHOXY-5-METHYLPHENOL Chemical Properties

Melting point:

59-63 °C (lit.)

Boiling point:

259 °C(Press: 755 Torr)

Density 

1.1106 g/cm3(Temp: 15 °C)

solubility 

Very slightly soluble in water, soluble in alcohol and oils

pka

9.70±0.10(Predicted)

form 

powder to crystal

color 

White to Almost white

Specific Gravity

1.11

Odor

at 10.00 % in dipropylene glycol. oakmoss fruity iodine woody hay

Odor Type

mossy

LogP

2.385 (est)

CAS DataBase Reference

3209-13-0(CAS DataBase Reference)

EPA Substance Registry System

Phenol, 3-methoxy-5-methyl- (3209-13-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39-37

WGK Germany 

2

TSCA 

Yes

HS Code 

29095090

3-METHOXY-5-METHYLPHENOL Usage And Synthesis

Chemical Properties

Crystalline powder

Uses

3-Methoxy-5-methylphenol (cas# 3209-13-0) is a compound useful in organic synthesis.

Definition

ChEBI: 3-Methoxy-5-methylphenol is a member of phenols and a member of methoxybenzenes.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 6, p. 859, 1988
The Journal of Organic Chemistry, 49, p. 1672, 1984 DOI: 10.1021/jo00183a043
Tetrahedron Letters, 11, p. 1327, 1970

Synthesis

A solution of anhydrous orcinol (12.4 g,0.1 mole) in dry acetone (100 ml)is refluxed for 4 hr with dimethyl sulphate (10.63 ml，14.2 g,0.112 mole) and ignited potassium carbonate (20 g) under anhydrous conditions. The mixture is filtered in hot, and the inorganic salts are washed with hot acetone(25 ml). The combined acetone solution is distilled. The oily product is purified by column chromatography over silica gel using chloroform as aneluant. Orcinol monomethyl ether is obtained as oil. Yield 4.2 g (30.4%).

3-METHOXY-5-METHYLPHENOL(3209-13-0)Related Product Information

• 3,5-Dimethoxybenzonitrile
• 3-Hydroxy-4,5-dimethoxybenzoic acid
• 3,4,5-Trimethoxyphenylacetic acid
• Syringic acid
• 3,5-DIMETHOXYBENZOYL CHLORIDE
• 3,4,5-Trimethoxyphenylacetonitrile
• Colchicine
• 3,4,5-TRIMETHOXYCINNAMIC ACID
• 3,4,5-Trimethoxybenzonitrile
• 3,5-Dimethoxybenzoic acid
• 3-(3,4,5-TRIMETHOXYPHENYL)PROPIONIC ACID
• 3,4,5-Trimethoxybenzoyl chloride
• 3,5-DIMETHOXYCINNAMIC ACID
• 3,5-Dimethoxybenzaldehyde
• 4-Hydroxy-3,5-dimethoxycinnamic acid
• 3,4,5-Trimethoxybenzaldehyde
• 3,4,5-Trimethoxy benzoic acid
• 2-Methoxy-4-methylphenol acetate