5-Bromo-2'-deoxycytidine Chemical Properties

Boiling point:

510.8±60.0 °C(Predicted)

Density 

2.12±0.1 g/cm3(Predicted)

RTECS 

HA3705000

storage temp. 

Store at 0°C

pka

14.03±0.60(Predicted)

form 

Powder

color 

White to Pale Yellow

CAS DataBase Reference

1022-79-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

HS Code 

29389090

5-Bromo-2'-deoxycytidine Usage And Synthesis

Uses

5-Bromo-2'-deoxycytidine (BrdC) is a brominated derivative of the deoxyribonucleoside 2’-deoxycytidine. It induces DNA cross-linking and the formation of DNA strand breaks when incorporated into a DNA fragment in place of cytosine and exposed to UVB damage. BrdC inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 in infected primary rabbit kidney (PRK) cells (MICs = 0.2-0.3 μg/ml). It decreases the survival of U-1 melanoma cells and AG1522 non-cancerous cells and induces sensitization of both to radiation. BrdC also sensitizes tumors to radiation and reduces tumor volume in a mouse model of glioma using RT-2 cells infused with an adenovirus expressing HSV thymidine kinase (ADV-TK) after implantation. In vivo, BrdC is converted to 5-bromo-2'-deoxyuridine (BrdU) and has been used to label cardiac progenitor cells (CPCs) in a rat model of myocardial infarction.

5-Bromo-2'-deoxycytidine(1022-79-3)Related Product Information

• Zalcitabine
• Cytidine 5’-monophosphate
• Tris(hydroxymethyl)aminomethane
• 2'-Deoxycytidine
• Cytidine-5'-triphosphate disodium salt dihydrate
• Glycine
• 5-Azacytidine
• 6-Aminocaproic acid
• CHLOROPHOSPHONAZO III
• Cytarabine
• Tris(hydroxymethyl)nitromethane
• ALTRENOGEST
• Cytidine
• Bromine
• Cytosine
• 2'-Deoxycytidine
• 5-BROMOCYTIDINE
• 5-Bromo-2'-deoxycytidine