ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Basic information
- Product Name:
- (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
- Synonyms:
-
- (2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
- Clopidogrel thiolactone
- Clopidogrel Impurity 57
- 2-OXO-CLOPIDOGREL; CLOPIDOGREL THIOLACTONE; 2-OXOCLOPIDOGREL
- 2S-Oxo Clopidogrel Hydrochloride
- Methyl (2S)-2-(2-chlorophenyl)-2-(2-oxo-4,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate
- Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-, methyl ester, (αS)-
- Methyl (αS)-α-(2-Chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate
- CAS:
- 1147350-75-1
- MF:
- C16H16ClNO3S
- MW:
- 337.82
- Mol File:
- 1147350-75-1.mol
More
Less
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Chemical Properties
- Boiling point:
- 488.1±45.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 50 mg/mL (148.01 mM); Water: < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 3.41±0.20(Predicted)
- color
- Brown to reddish brown
More
Less
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate Usage And Synthesis
Uses
Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
in vivo
Clopidogrel thiolactone (8 μm/kg; i.v.) has good biological availability and pharmacokinetic parameters in Sprague-Dawley male rats[1].
| Animal Model: | Sprague-Dawley male rats[1] |
| Dosage: | 8 μm/kg; with orally clopidogrel (24 μm/kg) |
| Administration: | Intravenous injection; collected blood at 0 h (before dosing) and 0.083, 0.167, 0.5, 1, 2, 4, 6, 8, 24 h postdose. |
| Result: | 1.19 |
IC 50
P2Y12 Receptor
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetateSupplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Nanjing Norris-Pharm Technology Co., Ltd
- Tel
- 18652989687
- sales@norris-pharm.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
EnliPharma Technology Co., Ltd
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
Quality Control Solutions Ltd.
- Tel
- 66853366 13670046396
- sales@chem-strong.com