Basic information Local anesthetic drug Chemical Properties Uses Production method Safety Supplier Related
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Prilocaine

Basic information Local anesthetic drug Chemical Properties Uses Production method Safety Supplier Related

Prilocaine Basic information

Product Name:
Prilocaine
Synonyms:
  • astra1512
  • o-Propionotoluidide, 2-(propylamino)- (6CI, 8CI)
  • Propanamide, N-(2-methylphenyl)-2-(propylamino)- (9CI)
  • N-(2-methylphenyl)-2-(propylamino)propionamide
  • Prilocaine (200 mg)
  • 2-(PropylaMino)-N-(o-tolyl)propanaMide
  • Prilocaine HCl (base)
  • Prilocaine N-(2-Methylphenyl)-2-propylamino-propanamide
CAS:
721-50-6
MF:
C13H20N2O
MW:
220.31
EINECS:
211-957-0
Product Categories:
  • Pharmaceutical Intermediates
  • Inhibitors
  • Active Pharmaceutical Ingredients
  • research chemical
  • API
  • 721-50-6
Mol File:
721-50-6.mol
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Prilocaine Chemical Properties

Melting point:
37-38°
Boiling point:
bp0.1 159-162°
Density 
1.0117 (rough estimate)
refractive index 
nD20 1.5298
storage temp. 
2-8°C
solubility 
Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
form 
neat
pka
pKa 7.32 or 7.89 (Uncertain)
Water Solubility 
6.169g/L(25 ºC)
InChIKey
MVFGUOIZUNYYSO-UHFFFAOYSA-N
CAS DataBase Reference
721-50-6(CAS DataBase Reference)
NIST Chemistry Reference
Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)
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Safety Information

HS Code 
2924296000
Hazardous Substances Data
721-50-6(Hazardous Substances Data)
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Prilocaine Usage And Synthesis

Local anesthetic drug

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6~7min and the duration time of about 1.5~2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta.
[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring.
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia.
[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.

Figure 1 the structural formula of prilocaine
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.

Uses

It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.

Production method

O-toluidine and α-bromo-propionyl bromide are condensed and further have reaction with propylamine obtain prilocaine.

Chemical Properties

White or almost white, crystalline powder.

Uses

Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.

Uses

In terms of pharmacological parameters, prilocaine is comparable to lidocaine; however, because of a number of toxic manifestations, it is rarely used in medical practice. Citanest and xylonest are well-known synonyms for prilocaine.

Definition

ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

General Description

Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.

Pharmacology

Prilocaine is less toxic than lidocaine, with a high clearance, attributable to metabolism in the lungs, kidneys and liver. It is associated with methaemoglobinaemia at doses >600mg. It is sometimes used at a concentration of 0.5% for the provision of intravenous regional anaesthesia, and a combination of prilocaine 3% with felypressin is available for low-volume local infiltration anaesthesia in dental surgery. A 2% formulation is also available for spinal anaesthesia. Prilocaine is also formulated in a eutectic mixture with lidocaine (EMLA) for topical anaesthesia.

Clinical Use

Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.

Synthesis

Prilocaine, 2-(propylamino)-o-propiontoluidine (2.2.14), is structurally related to the exact same group as ethidocaine, yet it differs structurally in that during synthesis, o-toluidine is used instead of 2,6-dimethylaniline, and instead of a butyric acid, a fragment of propionic acid, and a terminal propylethylamine group is replaced with a propylamine group. In order to synthesize prilocaine, o-toluidine is reacted with bromopropionyl bromide, and the resulting bromopropionyltoluidide (2.2.13) is then reacted with propylamine, which gives prilocaine [22,23].

Prilocaine Preparation Products And Raw materials

Raw materials

PrilocaineSupplier

Shandong RuiYue Biotechnology Co., Ltd. Gold
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0531-88581623 18805314509
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1456922171@126.com
Wuhan Bo Jin Biotechnology Co.,Ltd. Gold
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15623803827
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2709603029@qq.com
Shandong Mingfeng Pharmaceutical and Technology Co. Ltd Gold
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qq-13454566-43 15315114555
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1345456643@qq.com
Changzhou Sunlight Farmacéutica.S.L. Gold
Tel
0519-83138357,348846435 13706121722
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810308@sunlightchem.com
Jinan Chenghui Shuangda Chemical Co., Ltd.
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0531-58897086 15098872635
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444791477@qq.com