(R)-1-(3-Bromophenyl)ethylamine Chemical Properties

Boiling point:

96°C/4mm

Density 

1.33

Flash point:

96°C/4mm

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.73±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

optical activity

Consistent with structure

Sensitive 

Air Sensitive

Safety Information

Hazard Codes 

C,N

Risk Statements 

34-51/53-43-22

Safety Statements 

26-36/37/39-61-45

RIDADR 

2735

HazardClass 

8

PackingGroup 

III

(R)-1-(3-Bromophenyl)ethylamine Usage And Synthesis

Synthesis

The general procedure for the synthesis of (R)-1-(3-bromophenyl)ethylamine from 1-(3-bromophenyl)ethanone oxime is as follows: 1 equiv. of N-[1-(3-bromophenyl)ethylidene]hydroxylamine, 5 mol% of RuCl(Cymene)(S-tol-Binap)Cl catalyst, 5 equiv. of additives, and 70 vol. of methanol (relative to the amount of the oxime) are added to a glass vial. The glass vials were placed in a parallel autoclave, which was pressurized to 30 bar with hydrogen, then heated to 90 °C and kept for 24 hours. After completion of the reaction, the system was cooled to 20 °C. The reaction mixture was diluted with isopropyl alcohol. The reaction mixture was diluted with isopropanol and analyzed by chiral HPLC.

References

[1] Patent: WO2015/178847, 2015, A1. Location in patent: Page/Page column 7-8

(R)-1-(3-Bromophenyl)ethylamine(176707-77-0)Related Product Information

• Triethylamine
• L-1-Phenylethylamine
• Diethylamine
• Triphenylphosphine
• Ethambutol
• Ethylamine
• 2-Phenylphenol
• Phenylacetone
• (R)-2-(3-BROMOPHENYL)PYRROLIDINE
• 1-(4-Bromophenyl)ethylamine hydrochloride
• (R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE HYDROCHLORIDE
• (S)-(-)-1-(2-Bromophenyl)ethylamine
• (S)-1-(3-Bromophenyl)ethylamine, ChiPros 99%, ee 98+%,(S)-1-(3-BROMOPHENYL)ETHYLAMINE
• 4-Bromo-alpha-phenethylamine
• 2-(4-BROMOPHENYL)ETHYLAMINE
• 2-(2,5-Dimethoxy-4-bromophenyl)ethylamine Hydrochloride
• (S)-(-)-4-Bromo-alpha-phenylethylamine
• FMOC-(R)-3-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID