Azido-PEG11-azide Chemical Properties

form 

Liquid

color 

Colorless to light yellow

Azido-PEG11-azide Usage And Synthesis

Description

Azido-PEG11-azide is a aqueous soluble, monodisperse PEG linker containing two azide groups.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

Azido-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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