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6-HYDROXYFLAVONE

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6-HYDROXYFLAVONE Basic information

Product Name:
6-HYDROXYFLAVONE
Synonyms:
  • 6-hydroxy-2-phenyl-4H-chroMen-4-one
  • 6-Hydroxyflavone 98%
  • HYDROXYFLAVONE, 6-
  • 6-HYDROXYFLAVONE
  • 6-hydroxy-2-phenyl-4-benzopyrone
  • 6-Hydroxyflavone,98%
  • HYDROXYFLAVONE, 6-(RG)
  • TIMTEC-BB SBB000766
CAS:
6665-83-4
MF:
C15H10O3
MW:
238.24
EINECS:
229-704-8
Product Categories:
  • Inhibitors
  • H
  • Heterocyclic Building Blocks
  • Mono-substituted Flavones
  • Biochemistry
  • Flavonoids
  • Benzopyrans
  • Building Blocks
  • Heterocyclic Building Blocks
  • Bioactive Small Molecules
  • Building Blocks
  • Cell Biology
  • Chemical Synthesis
Mol File:
6665-83-4.mol
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6-HYDROXYFLAVONE Chemical Properties

Melting point:
234-236 °C (lit.)
Boiling point:
320.83°C (rough estimate)
Density 
1.2653 (rough estimate)
refractive index 
1.5740 (estimate)
pka
8.98±0.40(Predicted)
form 
powder to crystal
color 
Light yellow to Yellow to Green
BRN 
15827
LogP
4.445 (est)
CAS DataBase Reference
6665-83-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
2932.99.7000

MSDS

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6-HYDROXYFLAVONE Usage And Synthesis

Chemical Properties

light yellow crystals

Uses

anxiolytic

Definition

ChEBI: 6-Hydroxyflavone is a hydroxyflavonoid.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 2751, 1986 DOI: 10.1016/S0040-4039(00)84634-1

in vivo

6-Hydroxyflavone (6-100 mg/kg; Oral administration; Single dose; 45 minutes before test) has anti-anxiety effect in mouse model[4].
6-Hydroxyflavone (25-50 mg/kg; Intraperitoneal injection; 15 days) shows protective effect in Cisplatin (HY-17394) -induced nephrotoxicity rat model[5].

Animal Model:Male ICR mice (20-36 g)[4]
Dosage:6, 12, 25, 50 and 100 mg/kg
Administration:Oral administration (p.o.); Single dose; 45 minutes before test
Result:Showed anti-anxiety effects on behavioral tests.
Animal Model:Cisplatin (HY-17394) treated male Sprague-Dawley rats (200-250 g)[5]
Dosage:25 and 50 mg/kg
Administration:Intraperitoneal injection (i.p.); 15 days
Result:Significantly attenuated the Cisplatin associated detrimental changes in the body weight, and serum levels of creatinine and urea at both 25 mg/kg and 50 mg/kg.
Preserved the renal histoarchitecture from the toxicological influence of Cisplatin.
Reduced the Cisplatin-induced lipid peroxidation and corrected the renal antioxidant status.

6-HYDROXYFLAVONESupplier

J & K SCIENTIFIC LTD.
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