5-AMINO-4-CHLOROPYRIMIDINE Chemical Properties

Melting point:

110-116℃

Boiling point:

253.8±20.0 °C(Predicted)

Density 

1.437±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

1.30±0.16(Predicted)

form 

Solid

color 

White to pale brown

Sensitive 

Air & Light Sensitive

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-39

WGK Germany 

3

HS Code 

29335990

5-AMINO-4-CHLOROPYRIMIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-amino-4-chloropyrimidine from 5-amino-6-chloropyrimidine-4-thiol: The concentrated product of Example 18 (4.3 g, 26 mmol) was dissolved in EtOH (40 mL). Subsequently, NH4OH (4 mL) was added to this solution. Under stirring, an excess of Raney Nickel was added in batches. the reaction mixture was stirred overnight at room temperature and then heated at 80 °C for 2 h. The reaction was carried out at room temperature. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The crude product was purified by silica fast chromatography using EtOAc/hexane as eluent to give 1.6 g (47% yield) of 5-amino-4-chloropyrimidine as a yellow solid.

References

[1] Patent: US2006/13799, 2006, A1. Location in patent: Page/Page column 59
[2] Patent: WO2006/127584, 2006, A1. Location in patent: Page/Page column 61; 89
[3] Patent: WO2007/8563, 2007, A2. Location in patent: Page/Page column 88

5-AMINO-4-CHLOROPYRIMIDINE(54660-78-5)Related Product Information

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