- Product Name:
- 2-(4-Aminobenzenesulfonamido)pyridine N'-2-Pyridylsulfanilide 2-Sulfanilamidopyridine
- Sulfapyridine Solution, 100ppm
- Monoclonal Anti-THAP11 antibody produced in mouse
- Sulfapyridine (Dagenan)
- Product Categories:
- Aromatics Compounds
- Sulfur & Selenium Compounds
- Intermediates & Fine Chemicals
- Mol File:
Sulfapyridine Chemical Properties
- Melting point:
- Boiling point:
- 473.5±51.0 °C(Predicted)
- 1.3220 (rough estimate)
- refractive index
- 1.6740 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pKa 8.48(H2O t = 25 I = 0.05) (Uncertain)
- Water Solubility
- <0.1 g/100 mL at 22 ºC
- Stable. Combustible. Protect from light. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 144-83-2(CAS DataBase Reference)
- NIST Chemistry Reference
- EPA Substance Registry System
- Sulfapyridine (144-83-2)
Sulfapyridine Usage And Synthesis
White to Off-White Solid
Used in treatment of dermatitis herpetiformis; antibacterial.
antibacterial, dermatitis herpetiformis therapy
ChEBI: A sulfonamide consisting of pyridine with a 4-aminobenzenesulfonamido group at the 2-position.
Like all sulfanilamides, this drug possesses antibacterial activity with respect to streptococci, pneumococci, staphylococci, meningococci, gonococci, colon bacillus, pathogenic dysentery, and so on. It is a long-lasting drug. Synonyms of this drug are bacillopirin, plurazol, sulfidin, and thiaseptol.
Sulfapyridine’s plasma half-life is 9 hours.This compound is a white, crystalline, odorless, and tastelesssubstance. It is stable in air but slowly darkens on exposureto light. It is soluble in water (1:3,500), in alcohol(1:440), and in acetone (1:65) at 25°C. It is freely soluble indilute mineral acids and aqueous solutions of sodium andpotassium hydroxide. The pKa is 8.4. Its outstanding effectin curing pneumonia was first recognized by Whitby; however,because of its relatively high toxicity, it has been supplantedlargely by sulfadiazine and sulfamerazine. Severalcases of kidney damage have resulted from acetylsulfapyridinecrystals deposited in the kidneys. It also causes severenausea in most patients. Because of its toxicity, it is usedonly for dermatitis herpetiformis.
Sulfapyridine was the first drug to have an outstandingcurative action on pneumonia. It gave impetus to the studyof the whole class of N1 heterocyclically substituted derivativesof sulfanilamide.
Odorless or almost odorless white or yellowish-white crystalline powder. Very slightly bitter taste. Aqueous solution is neutral.
Air & Water Reactions
Insoluble in water.
Sulfapyridine is an amino acid. Slowly darkens on exposure to light . Soluble in both acidic and basic aqueous solutions
Flash point data for Sulfapyridine are not available; however, Sulfapyridine is probably combustible.
Moderately toxic by intraperitoneal and intravenous routes. Slightly toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and SOx.
Sulfapyridine, N1 -(2-pyridyl)-sulfanilamide (33.1.21), is also synthesized by an analogous scheme from 4-acetylaminobenzenesulfonyl chloride and 2-amino pyridine.
Crystallise sulfapyridine from 90% acetone and dry it at 90o. Its solubility in Me2CO, EtOH and H2O is 1.5%, 0.22% and 0.02%, respectively. [Winterbottom J Am Chem Soc 62 160 1940, Beilstein 22 III/IV 3978.]
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