Basic information Safety Supplier Related

E3 ligase Ligand-Linker Conjugates 4

Basic information Safety Supplier Related

E3 ligase Ligand-Linker Conjugates 4 Basic information

Product Name:
E3 ligase Ligand-Linker Conjugates 4
Synonyms:
  • E3 ligase Ligand-Linker Conjugates 4
  • VHL Ligand-Linker Conjugates 5
  • VH032-PEG4-N3
  • (2S,4R)-1-((S)-17-azido-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
  • L-Prolinamide, N-(14-azido-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
CAS:
1797406-81-5
MF:
C32H47N7O8S
MW:
689.83
Mol File:
1797406-81-5.mol
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E3 ligase Ligand-Linker Conjugates 4 Chemical Properties

form 
Liquid
color 
Colorless to off-white
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E3 ligase Ligand-Linker Conjugates 4 Usage And Synthesis

Description

UUN06815, also known as (S,R,S)-AHPC-PEG4-Azide, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment.

E3 ligase Ligand-Linker Conjugates 4Supplier

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