E3 ligase Ligand-Linker Conjugates 6 Chemical Properties

storage temp. 

2-8°C

form 

Solid

color 

White to yellow

E3 ligase Ligand-Linker Conjugates 6 Usage And Synthesis

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG₂-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 6(2097973-72-1)Related Product Information

• E3 ligase Ligand-Linker Conjugates 50
• E3 Ligase Ligand-Linker Conjugates 21
• E3 ligase Ligand-Linker Conjugates 13
• E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
• E3 ligase Ligand-Linker Conjugates 4
• E3 Ligase Ligand-Linker Conjugates 19
• E3 ligase Ligand-Linker Conjugates 7 Free Base
• E3 Ligase Ligand-Linker Conjugates 22
• E3 ligase Ligand-Linker Conjugates 11