5-Fluoro-2-methylpyridine Chemical Properties

Boiling point:

135-136 C

Density 

1.077g/ml

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

liquid

pka

3.53±0.10(Predicted)

color 

Clear, almost colourless

CAS DataBase Reference

31181-53-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HazardClass 

IRRITANT

HS Code 

2933399990

5-Fluoro-2-methylpyridine Usage And Synthesis

Synthesis

5-Amino-2-methyl pyridine (2.8 g, 25.9 mmol) was added to a mixture of water (15 mL) and cone. HCl (7 mL) and cooled to 0°C. NaNO2 (3.5 g, 51.8 mmol) was added portion-wise with stirring over 10 min whilst keeping the reaction temperature between -5℃ and O℃. After stirring for 10 min 60 % w/w HPF6 (14 mL) was added dropwise with cooling, at which point a precipitate formed. This was filtered, washed with cold water and diethyl ether and dried. The solid was then heated slowly to 100℃; the reaction being very exothermic. After 5 min a dark red oily material formed which was then cooled to r.t. The oil was basifed with dilute sodium hydroxide to pH ~10 and extracted with dichloromethane. The combined organics were dried over sodium sulfate, filtered and evaporated in vacuo. The residue was purified by column chromatography over neutral alumina using 20 % dichloromethane-petroleum ether to yield 5-fluoro-2- methyl pyridine (1.57 g, 55%) as an oil.

5-Fluoro-2-methylpyridine(31181-53-0)Related Product Information

• 3-Fluoropyridine
• 2-Picoline
• 2-(Trifluoromethyl)benzoic acid
• 4-Methylpyridine
• 3-(Trifluoromethyl)benzaldehyde
• 2-Chloro-5-chloromethylpyridine
• Azamethiphos
• Methyl propyl carbonate
• 2,6-Lutidine
• 2,4,6-Collidine
• Flupirtine
• Fluorine
• 2-bromo-3-fluoro-6-methylpyridine
• 5-FLUORO-2-PICOLINIC ACID
• 3,5-Difluoropicolinic acid
• 2-chloro-3-fluoro-6-methylpyridine
• 5-Fluoro-2-forMylpyridine
• 2-Cyano-3,5-difluoropyridine