5-Fluoro-2-methylpyridine
5-Fluoro-2-methylpyridine Basic information
- Product Name:
- 5-Fluoro-2-methylpyridine
- Synonyms:
-
- 2-methyl-5-fluoro-pyridine
- 5-Fluoro-2-methylpyridine 98+%
- 3-FLUORO-6-METHYLPYRIDINE (3-FLUORO-6-PICOLINE)
- 5-FLUORO-2-METHYLPYRIDINE (5-FLUORO-2-PICOLINE)
- 5-FLUORO-2-PICOLINE5-FLUORO-2-METHYLPYRIDINE
- 5-FLUORO-2-METHYLPYRIDINE
- 5-FLUORO-2-PICOLINE
- 3-FLUORO-6-METHYLPYRIDINE
- CAS:
- 31181-53-0
- MF:
- C6H6FN
- MW:
- 111.12
- Product Categories:
-
- Pyridines
- Pyridine
- Mol File:
- 31181-53-0.mol
5-Fluoro-2-methylpyridine Chemical Properties
- Boiling point:
- 135-136 C
- Density
- 1.077g/ml
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- 3.53±0.10(Predicted)
- color
- Clear, almost colourless
- CAS DataBase Reference
- 31181-53-0(CAS DataBase Reference)
5-Fluoro-2-methylpyridine Usage And Synthesis
Synthesis
5-Amino-2-methyl pyridine (2.8 g, 25.9 mmol) was added to a mixture of water (15 mL) and cone. HCl (7 mL) and cooled to 0°C. NaNO2 (3.5 g, 51.8 mmol) was added portion-wise with stirring over 10 min whilst keeping the reaction temperature between -5℃ and O℃. After stirring for 10 min 60 % w/w HPF6 (14 mL) was added dropwise with cooling, at which point a precipitate formed. This was filtered, washed with cold water and diethyl ether and dried. The solid was then heated slowly to 100℃; the reaction being very exothermic. After 5 min a dark red oily material formed which was then cooled to r.t. The oil was basifed with dilute sodium hydroxide to pH ~10 and extracted with dichloromethane. The combined organics were dried over sodium sulfate, filtered and evaporated in vacuo. The residue was purified by column chromatography over neutral alumina using 20 % dichloromethane-petroleum ether to yield 5-fluoro-2- methyl pyridine (1.57 g, 55%) as an oil.
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5-Fluoro-2-methylpyridine(31181-53-0)Related Product Information
- 3-Fluoropyridine
- 2-Picoline
- 2-(Trifluoromethyl)benzoic acid
- 4-Methylpyridine
- 3-(Trifluoromethyl)benzaldehyde
- 2-Chloro-5-chloromethylpyridine
- Azamethiphos
- Methyl propyl carbonate
- 2,6-Lutidine
- 2,4,6-Collidine
- Flupirtine
- Fluorine
- 2-bromo-3-fluoro-6-methylpyridine
- 5-FLUORO-2-PICOLINIC ACID
- 3,5-Difluoropicolinic acid
- 2-chloro-3-fluoro-6-methylpyridine
- 5-Fluoro-2-forMylpyridine
- 2-Cyano-3,5-difluoropyridine