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SOPHORIDINE

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SOPHORIDINE Basic information

Product Name:
SOPHORIDINE
Synonyms:
  • Sophoridine
  • (5-beta)-Matridin-15-one
  • Matridin-15-one, (5-beta)- (9ci)
  • Sophoridin
  • SOLSTITIALIN A 13-ACETATE(SH)(CALL)
  • OPHORIDINE
  • Sophoridine, 98%, from Sophora alopecuroides L.
  • 5-EPIDIHYDROSOPHOCARPINE
CAS:
6882-68-4
MF:
C15H24N2O
MW:
248.36
EINECS:
683-139-5
Product Categories:
  • Alkaloids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
6882-68-4.mol
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SOPHORIDINE Chemical Properties

Melting point:
109-110 °C
Boiling point:
396.7±31.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in ethanol, methanol and water
form 
powder to crystal
pka
9.47±0.20(Predicted)
color 
White to Light yellow
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Safety Information

Safety Statements 
24/25
HS Code 
29399990
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SOPHORIDINE Usage And Synthesis

Description

Sophoridine is a quinolizidine alkaloid isolated from traditional Chinese herbs, which exists in the stems and leafs of Leguminous plant Sophora alopecuroides L., Euchresta japonica Benth., and the roots of Sophora alopecuroides Ait. Sophoridine-induced synchronous oscillations in the hippocampus could elicit the generation and development of seizure. Accumulating evidence demonstrates remarkable pharmacological effects of Sophoridine, including anti-inflammatory, anti-virus and anti-cancer effects.

Uses

(-)Sophoridine is an anticancer agent, with a promising anti-rumor effect and lower toxicity. Anti-inflammatory.

Definition

Sophoridine is a quinolizidine alkaloid isolated from leafs of Leguminous plant Sophora alopecuroides.L. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor drug candidate for pancreatic cancer with well-tolerated toxicity.

General Description

Sophoridine, a natural anticancer drug, has been used in China for decades. A series of novel N-substituted Sophoridinic acid derivatives were synthesized and evaluated for their cytotoxicity with 1 as the lead. The structure-activity relationship indicated that introduction of an aliphatic acyl on the nitrogen atom might significantly enhance the anticancer activity. Among the compounds, 6b bearing bromoacetyl side-chain afforded a potential effect against four human tumor cell lines (liver, colon, breast, and lung). The mechanism of action of 6b is to inhibit the activity of DNA topoisomerase I, followed by the S-phase arrest and then cause apoptotic cell death, similar to that of its parent 1.

Biological Activity

Sophoridine is promising to be a novel, potent and selective antitumor drug candidate for pancreatic cancer. It was shown that sophoridine is able to suppress hepatocellular carcinoma in vitro and vivo. Sophoridine dose- and time-dependently blocks the RANKL-induced osteoclasts formation and the activation of ERK and c-Fos as well as the induction and nucleus translocation of NFATc1.

Mechanism of action

Sophoridine is an active quinolizidine alkaloid isolated from leaves of Leguminous plant Sophora alopecuroides. L. Accumulating evidence demonstrated that Sophoridine displays remarkable pharmacological effects in inflammatory diseases , infectious diseases and cancers . In particular, Sophoridine and its derivatives have drawn more and more attention owing to their potent anti-tumor effects in different tumor cell lines and animal models. The underlying anti-tumor mechanisms of Sophoridine including increase of intracellular ROS levels, activation of the phosphorylation of ERK and JNK, induction of S phase arrest in pancreatic cancer cells; inhibition of growth and invasion in human colorectal cancer cells via directly binding to MAPKAPK2 and inactivates its phosphorylation; inhibition of ubiquitin-proteasome pathway in human glioma cells.

in vitro

Sophoridine (0-500 μM; 48 hours) exhibits remarkable inhibition effects to the growth of human pancreatic, gastric, liver, colon, gallbladder, and prostate carcinoma cells with IC50 values of about 20 μM to 200 μM.Sophoridine (0-20 μM; 48 hours) increases S phase cell population from 26.23% (control) to 38.67% in Miapaca-2 cells and from 29.56% (control) to 39.16% in PANC-1 cells, about a 1.5-fold and a 1.3-fold increase, respectively.Sophoridine (0-20 μM; 48 hours) significantly increases bad and bax levels, and decreases bcl-2 and bcl-xl levels in contrast, with a significant increase in Bax/Bcl-2 ratio.

Source

Sophoridine is a bioactive alkaloid found in many Chinese herbs, such as Sophora alopecuroides l, Euchresta japonica Benth and Sophora moocrorftinan. Sophoridine hydrochloride injection has been approved as an anticancer drug in China.

SOPHORIDINESupplier

Nanjing Duolong Bio-tech Co.,Ltd. Gold
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18905173768
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sales@dolonchem.com
Chembest Research Laboratories Limited
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+86-21-20908456
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com
Sichuan Kulinan Technology Co., Ltd
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400-1166-196 18981987031
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cdhxsj@163.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com