Peptide T
Peptide T Basic information
- Product Name:
- Peptide T
- Synonyms:
-
- ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE
- L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-
- L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-
- Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt
- PEPTIDE T
- CAS:
- 106362-32-7
- MF:
- C35H55N9O16
- MW:
- 857.86
- Mol File:
- 106362-32-7.mol
Peptide T Chemical Properties
- Boiling point:
- 1499.5±65.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- pka
- 3.21±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr
Peptide T Usage And Synthesis
Description
Peptide T is an HIV entry inhibitor derived from the envelope glycoprotein gp120 of human immunodeficiency virus. It is potentially useful as antiviral agent in AIDS therapy. The core pentapeptide sequence, TTNYT, consisting of amino acids 4-8 in peptide T, is the HIV envelope sequence required for attachment to the CD4 receptor.
Uses
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
in vivo
Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].
IC 50
HIV-1
References
[1] Ruff MR, et al. Peptide T[4-8] is core HIV envelope sequence required for CD4 receptor attachment. Lancet. 1987 Sep 26;2(8561):751. DOI:10.1016/s0140-6736(87)91120-2
[2] Ruff MR, et al. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 2001 Oct;52(1):63-75. DOI:10.1016/s0166-3542(01)00163-2
[3] Raychaudhuri SP, et al. Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines. Int J Immunopharmacol. 1999 Sep;21(9):609-15. DOI:10.1016/s0192-0561(99)00041-7
[4] Sáez-Torres I, et al. Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Clin Exp Immunol. 2000 Jul;121(1):151-6. DOI:10.1046/j.1365-2249.2000.01259.x
Peptide TSupplier
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 021-58955995
- sales@medchemexpress.cn
- Tel
- info@creative-peptides.com
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Tel
- 17705183659
- sales@njleonbiotech.com
Peptide T(106362-32-7)Related Product Information
- Peptide M
- H-GLU-ARG-MET-ARG-PRO-ARG-LYS-ARG-GLN-GLY-SER-VAL-ARG-ARG-ARG-VAL-OH
- Val-cit-PAB-OH
- Peptide synthesis
- Peptide impurity
- peptide CRO
- OGP (Ostegenic Growth Peptide)
- Peptide phosphorylation marker
- Peptide fluorescent modification
- GMP peptide CMO
- FAEPLPSEEEGESYSKEVPEMEKRYGGFMRF
- Peptide 5
- PEPTIDE F (BOVINE)
- A20FMDV2
- peptide 78
- peptide 74
- AC-THR-OH
- H-ALA-ALA-TYR-ALA-OH