13-Acetyl-9-dihydrobaccatin III CAS#: 142203-65-4

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13-Acetyl-9-dihydrobaccatin III

Basic information Safety Supplier Related

13-Acetyl-9-dihydrobaccatin III Basic information

Product Name:

13-Acetyl-9-dihydrobaccatin III

Synonyms:

Cabazitaxel Impurity 55
9-Dideacetyl baccatin VI
2a,3,4,4a,5,6,9,10,12,12a-Decahydro-4a,8,13,13-tetramethyl-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxete-4,5,6,9,11,12,12b-heptol (2aR,4S,4aS,5R,6R,9S,11S,12S,12aR,12bS)-6,9,12b-triacetate 12-benzoate
13-Acetyl-9-dihydrobaccatin III
9-Dihydro-13-acetylbaccatinIII from Taxus canadensis
9-DIHYDRO-13-ACETYL BACCATIN(9-DHB)
7,9-Dideacetylbaccatin VI
19-DHB

CAS:

142203-65-4

MF:

C33H42O12

MW:

630.68

Product Categories:

Miscellaneous Natural Products

Mol File:

142203-65-4.mol

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13-Acetyl-9-dihydrobaccatin III Chemical Properties

Melting point:: 171-175°C
Boiling point:: 704.5±60.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.61±0.70(Predicted)
form: Solid
color: White
InChIKey: WPPPFZJNKLMYBW-FAEUQDRCSA-N
SMILES: O1C[C@@]2(OC(=O)C)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](OC(=O)C)C4)[C@@H](OC(=O)C)[C@H](O)[C@]3(C)[C@@H](O)C[C@@]12[H]

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Safety Information

RIDADR: 1544
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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13-Acetyl-9-dihydrobaccatin III Usage And Synthesis

Description

13-acetyl-9-Dihydrobaccatin III is a taxane originally isolated from T. canadensis. It inhibits proliferation of P388 leukemia cells with an IC₅₀ value of 20 μg/ml.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Taxus chinensis.

Uses

13-Acetyl-9-dihydrobaccatin-III is an apoptosis inducer.

References

[1] GEEWANANDA P. GUNAWARDANA. Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis[J]. Journal of Natural Products , 1992, 55 11: 1686-1689. DOI: 10.1021/np50089a022

13-Acetyl-9-dihydrobaccatin IIISupplier

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