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BENZAMIDINE

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BENZAMIDINE Basic information

Product Name:
BENZAMIDINE
Synonyms:
  • BENZAMIDINE
  • BENZENECARBOXIMIDAMIDE
  • phenylamidine
  • EINECS 210-546-3
  • benzenecarbonamidine
  • benzylamidine
  • Phenylmethanamidine
  • α-Iminobenzenemethanamine
CAS:
618-39-3
MF:
C7H8N2
MW:
120.15
EINECS:
210-546-3
Product Categories:
  • pharmacetical
  • Imines/Amidines
  • Nitrogen Compounds
  • Organic Building Blocks
  • B
  • Bioactive Small Molecules
  • Building Blocks
  • Cell Biology
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
618-39-3.mol
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BENZAMIDINE Chemical Properties

Melting point:
65-70 °C
Boiling point:
208.5±23.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
11.90±0.40(Predicted)
form 
powder or crystals
color 
White to Off-White
BRN 
606020
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
9-23
HS Code 
29299000

MSDS

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BENZAMIDINE Usage And Synthesis

Uses

Benzamidine was used in the preparation of heparan sulfate-rich proteoglycan from mouse mammary epithelial cells. It has been used to prevent enzymatic degradation during the purification procedure of bovine factor XII (Hageman factor).

Definition

ChEBI: Benzamidine is a carboxamidine that is benzene carrying an amidino group. It has a role as a serine protease inhibitor. It is a member of benzenes and a carboxamidine. It is functionally related to a benzoic acid. It is a conjugate base of a benzamidine(1+).

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 1255, 1962 DOI: 10.1021/jo01051a033
Tetrahedron Letters, 31, p. 1969, 1990 DOI: 10.1016/S0040-4039(00)88891-7

Biochem/physiol Actions

Benzamidine is an inhibitor of plasmin and has been used in the radioimmunoassay of glucagon in human plasma. It prevents the destruction of Thyrotropin-releasing hormone (TRH) added to whole blood in vitro before radioimmunoassay of TRH.

Purification Methods

It is liberated from its hydrochloride chloride (below) by treatment with 5M NaOH, extracted into diethyl ether, dried (Na2SO4) and sublimed in vacuo.[Beilstein 9 H 280, 9 I 123, 9 II 199, 9 1264, 9 IV 898.]

BENZAMIDINESupplier

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