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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Amino Acids and Derivatives >  Phenylalanine derivatives >  4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE

4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE

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4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Basic information

Product Name:
4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
Synonyms:
  • 4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE
  • MELPHALAN HCL
  • MELPHALAN HYDROCHLORIDE
  • phenylalaninemustardhydrochloride
  • Phenylalanine, 4-[bis(2-chloroethyl)amino]-, hydrochloride (1:1)
  • 2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANOIC ACID HYDROCHLORIDE (MELPHALAN HYDROCHLORIDE)
  • (S)-3-[4-[Bis(2-chloroethyl)amino]phenyl]alanine hydrochloride
  • Melphalan Hydrochloride (100 mg) (International Restricted Sales Item)
CAS:
3223-07-2
MF:
C13H19Cl3N2O2
MW:
341.66
EINECS:
643-091-8
Mol File:
3223-07-2.mol
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4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Chemical Properties

Melting point:
175-178 °C
solubility 
Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Moisture Sensitive
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Safety Information

Toxicity
TDLo orl-hmn: 1200 mg/kg/5D-I:GIT CCROBU57,369,73
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4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDE Usage And Synthesis

Uses

Melphalan Hydrochloride is used in combined intravitreal chemotherapy with topotecan hydrochloride for viable vitreous seeding from retinoblastoma. Also, it is an anti-cancer chemotherapy drug.

Safety Profile

Deadly poison by intravenousroute. Human systemic effects by ingestion: nausea andvomiting. Questionable carcinogen with experimentalcarcinogenic data. When heated to decomposition it emitsvery toxic fumes of Cl-, NOx, and HCl.

4-BIS(2-CHLORETHYL)-AMINO-L-PHENYLALANINE HYDROCHLORIDESupplier

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