Basic information Safety Supplier Related

BUCLIZINE

Basic information Safety Supplier Related

BUCLIZINE Basic information

Product Name:
BUCLIZINE
Synonyms:
  • Histabuticine
  • Histabutizine
  • Histabutyzine
  • Hitabutyzyne
  • Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-
  • piperazine,1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)
  • Postafen
CAS:
82-95-1
MF:
C28H33ClN2
MW:
433.03
EINECS:
201-448-1
Mol File:
82-95-1.mol
More
Less

BUCLIZINE Chemical Properties

Boiling point:
bp0.001 217-220°
Density 
0.9970 (rough estimate)
refractive index 
1.5940 (estimate)
pka
6.84±0.10(Predicted)
More
Less

BUCLIZINE Usage And Synthesis

Originator

Longifine,UCB

Uses

Buclizine is an antinauseant.

Definition

ChEBI: An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups.

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

Synthesis

Buclizine is mainly used in the prevention of motion sickness and in combination with analgesics for treatment of migraine.

BUCLIZINESupplier

Syntechem Co.,Ltd
Tel
Email
info@syntechem.com
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Email
waley188@sohu.com
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Email
cantotech@126.com
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Email
sales@chem-strong.com