WAY-607500 Chemical Properties

Boiling point:

574.7±50.0 °C(Predicted)

Density 

1.265±0.06 g/cm3(Predicted)

pka

12.93±0.20(Predicted)

WAY-607500 Usage And Synthesis

Uses

hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents[1].

IC 50

VEGFR1: 2.5 μM (IC₅₀); PDGF: 33.1 μM (IC₅₀)

References

[1] Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. DOI:10.1021/jm980123i

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