CIVENTICHEM CV-409 Chemical Properties

Boiling point:

649.1±55.0 °C(Predicted)

Density 

1.340±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 50 mg/mL (149.98 mM)

form 

Orange to red crystalline solid.

pka

12.93±0.20(Predicted)

color 

White to yellow

CIVENTICHEM CV-409 Usage And Synthesis

Uses

SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1). SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3].

IC 50

FGFR1: 10-20 μM (IC₅₀)

References

[1] Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60. DOI:10.1126/science.276.5314.955
[2] Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4. DOI:10.1046/j.1523-1747.2000.00888.x

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