ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > protein tyrosine kinase > PD168393
PD168393
PD168393 Basic information
- Product Name:
- PD168393
- Synonyms:
-
- 4-[(3-BROMOPHENYL)AMINO]-6-ACRYLAMIDOQUINAZOLINE
- PD 168393
- N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide
- PD168393;PD-168393;PD 168393
- CS-2316
- N-[4-(3-Bromoanilino)quinazolin-6-yl]prop-2-enamide
- PD-168393;PD 168393
- 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-
- CAS:
- 194423-15-9
- MF:
- C17H13BrN4O
- MW:
- 369.22
- Product Categories:
-
- Inhibitors
- Mol File:
- Mol File
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PD168393 Chemical Properties
- Melting point:
- 279℃
- Boiling point:
- 571.1±50.0 °C(Predicted)
- Density
- 1.558±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- insoluble in H2O; ≥1 mg/mL in EtOH with gentle warming and ultrasonic; ≥18.45 mg/mL in DMSO
- form
- powder
- pka
- 12.19±0.43(Predicted)
- color
- white to beige
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PD168393 Usage And Synthesis
Uses
PD 168393, is an irreversible epidermal growth factor receptor (EGFR) inhibitor.
Uses
PD168393 has been used in the acute inhibition of ErbB4.
Definition
ChEBI: A member of the class of quinazolines carrying bromoanilino and acrylamido substituents at positions 4 and 6 respectively.
Biochem/physiol Actions
PD168393 is a 6-acrylamido-4-anilinoquinazoline compound. It increases apoptosis in malignant peripheral nerve sheath tumor cells, stimulated by lysosomal dysfunction.
target
EGFR
PD168393Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
- Tel
- 21-57721279
- sales@shydchem.com.cn
Jinan Trio PharmaTech Co., Ltd.
- Tel
- +86 (531) 88811783
- sales@trio-pharmatech.com (International market)
Spectrum Chemical Manufacturing Corp.
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com