Basic information Safety Supplier Related

TYRPHOSTIN B48

Basic information Safety Supplier Related

TYRPHOSTIN B48 Basic information

Product Name:
TYRPHOSTIN B48
Synonyms:
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
  • A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE
  • A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
  • AG 494
  • N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
  • TYRPHOSTIN B48
  • TYRPHOSTIN AG 494
CAS:
133550-35-3
MF:
C16H12N2O3
MW:
280.28
Product Categories:
  • API
  • Intracellular Signaling
  • Protein Kinase
Mol File:
133550-35-3.mol
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TYRPHOSTIN B48 Chemical Properties

Melting point:
249 °C(dec.)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble
form 
Yellow solid.
color 
Light yellow to Amber to Dark green
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Safety Information

Safety Statements 
22-24/25
RIDADR 
3439
WGK Germany 
3
HS Code 
2926.90.4801
HazardClass 
6.1
PackingGroup 
III

MSDS

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TYRPHOSTIN B48 Usage And Synthesis

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells.

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).

References

[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.

TYRPHOSTIN B48Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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TCI (Shanghai) Development Co., Ltd.
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Adamas Reagent, Ltd.
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