TYRPHOSTIN B48
TYRPHOSTIN B48 Basic information
- Product Name:
- TYRPHOSTIN B48
- Synonyms:
-
- (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE
- ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
- A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE
- A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
- AG 494
- N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
- TYRPHOSTIN B48
- TYRPHOSTIN AG 494
- CAS:
- 133550-35-3
- MF:
- C16H12N2O3
- MW:
- 280.28
- Product Categories:
-
- API
- Intracellular Signaling
- Protein Kinase
- Mol File:
- 133550-35-3.mol
TYRPHOSTIN B48 Chemical Properties
- Melting point:
- 249 °C(dec.)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble
- form
- Yellow solid.
- color
- Light yellow to Amber to Dark green
Safety Information
- Safety Statements
- 22-24/25
- RIDADR
- 3439
- WGK Germany
- 3
- HS Code
- 2926.90.4801
- HazardClass
- 6.1
- PackingGroup
- III
MSDS
- Language:English Provider:SigmaAldrich
TYRPHOSTIN B48 Usage And Synthesis
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Biological Activity
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).
References
[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.
TYRPHOSTIN B48Supplier
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TYRPHOSTIN B48(133550-35-3)Related Product Information
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- TYRPHOSTIN B48
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- TYRPHOSTIN B48
- TIMTEC-BB SBB006283
- AURORA 9522
- AURORA 9504
- AURORA 8967
- AURORA 9549
- AURORA 9545
- AURORA 9521
- AURORA 9859
- AURORA 1302