SU 6668
SU 6668 Basic information
- Product Name:
- SU 6668
- Synonyms:
-
- SU 6668
- 3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
- 1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
- 5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid
- PDGFR Tyrosine Kinase Inhibitor VI, SU6668
- 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid
- PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem
- 3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
- CAS:
- 210644-62-5
- MF:
- C18H18N2O3
- MW:
- 310.35
- Mol File:
- 210644-62-5.mol
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SU 6668 Chemical Properties
- storage temp.
- +2C to +8C
- solubility
- DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
- form
- Dark yellow solid
- color
- Orange to red
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SU 6668 Usage And Synthesis
Uses
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.
General Description
A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 μM, respectively).
SU 6668Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Nanjing Chemlin Chemical Co., Ltd
- Tel
- 025-83697070
- info@chemlin.com.cn
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
- Tel
- 025-58196018 800028039
- sales@fartop.net
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
SPIRO PHARMA
- Tel
- eric_feng1954@126.com