X-376 Chemical Properties

Boiling point:

695.1±55.0 °C(Predicted)

Density 

1.428±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Ethanol:13.0(Max Conc. mg/mL);23.75(Max Conc. mM)

form 

A crystalline solid

pka

10.70±0.70(Predicted)

color 

White to off-white

X-376 Usage And Synthesis

Uses

X-376 is an ALK inhibitor with potential efficacy in the treatment of non-small cell lung cancer.

Side effects

The more common side effects of X-376 treatment include rash, itching, edema, and anemia.

Physiological effects

Ensatinib (X-376) is a second-generation tyrosine kinase inhibitor (TKI) small-molecule targeted drug targeting ALK fusion, which can selectively bind to the products of two driver gene mutations, ALK and MET. Block the activation and transmission of downstream signaling pathways, thereby inhibiting the growth and proliferation of cancer cells with these mutations, and exerting anti-cancer effects.

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