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Volitinib

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Volitinib Basic information

Product Name:
Volitinib
Synonyms:
  • AZD6094,Volitinib, HMPL-504, Savolitinib
  • 1-[(1S)-1-Imidazo[1,2-a]pyridin-6-ylethyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazolo[4,5-b]pyrazine
  • (S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine
  • Volitinib
  • Savolitinib
  • HMPL-504(AZD6094, Volitinib)
  • EOS-60799
  • AZD-6094)
CAS:
1313725-88-0
MF:
C17H15N9
MW:
345.36
Product Categories:
  • API
Mol File:
1313725-88-0.mol
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Volitinib Chemical Properties

Melting point:
205-207°C
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
5.67±0.50(Predicted)
form 
Solid
color 
Pale Beige
CAS DataBase Reference
1313725-88-0
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Volitinib Usage And Synthesis

Description

Savolitinib selectively inhibits the MET receptor, blocking the PI3K/AKT/MAPK-signaling pathway as well as downregulating MYC.

Uses

Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.

Clinical Use

It is currently being evaluated in phase I clinical trials in combination with EGFR TKIs in NSCLC patients.

VolitinibSupplier

DKMbiochem.Co. Ltd Gold
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15901859516
Email
sales@DKMbiochem.com
CAREBIO PHARMA Gold
Tel
18501057619
Email
771737847@qq.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
28-83379370 13880556291
Email
tcy@tcypharm.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
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Volitinib(1313725-88-0)Related Product Information