2-Fluoro-5-nitrobenzoic acid Chemical Properties

Melting point:

142-144 °C (lit.)

Boiling point:

337.7±27.0 °C(Predicted)

Density 

1.568±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in chloroform, ethanol.

pka

2.54±0.10(Predicted)

form 

Crystalline Powder

color 

White to pale yellow

BRN 

1912835

CAS DataBase Reference

7304-32-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29163990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Fluoro-5-nitrobenzoic acid Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.

Uses

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:

• dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (S_NAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
• synthesis of substituted dibenzazocines on solid support, via S_NAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
• in the synthesis of oxazepines

General Description

2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.

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