N-(Diphenylmethylene)glycerine tert-butyl ester Chemical Properties

Melting point:

51-53 °C(lit.)

Boiling point:

377.5±34.0 °C(Predicted)

Density 

1.00±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

2.31±0.50(Predicted)

form 

crystal

color 

white

Water Solubility 

Insoluble in water.

Stability:

Moisture Sensitive

InChI

InChI=1S/C19H21NO2/c1-19(2,3)22-17(21)14-20-18(15-10-6-4-7-11-15)16-12-8-5-9-13-16/h4-13H,14H2,1-3H3

InChIKey

YSHDPXQDVKNPKA-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)C/N=C(/C1=CC=CC=C1)\C1=CC=CC=C1

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

F 

10-21

TSCA 

No

HS Code 

29163990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-(Diphenylmethylene)glycerine tert-butyl ester Usage And Synthesis

Chemical Properties

White Solid

Uses

suzuki reaction

Uses

N-(Diphenylmethylene)glycine tert-butyl ester is a useful dye for biological research purposes. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Synthesis

The intermediate was synthesized by a general procedure based on US2010/0189644 and the disclosure of O'Donnell et al. The procedure was carried out as follows: benzophenone imine (8.6 g, 47.5 mmol), tert-butyl bromoacetate (9.3 g, 47.5 mmol), and acetonitrile (40 mL) were added to a round-bottomed flask equipped with a stirrer. After heating the reaction mixture to 70 °C, N,N-diisopropylethylamine (DIPEA, 8.3 mL, 47.5 mmol) was slowly added. A reflux condenser was installed and the reaction was maintained at 70 °C for 16 hours. The reaction progress was monitored by HPLC and TLC and after confirming the complete conversion of the reactants, the reaction mixture was cooled to room temperature. A 5:3 mixture of water/formic acid (1 mL) was added, followed by concentration of the reaction mixture under reduced pressure. The resulting solid was washed sequentially with 3:1 cold solution of water/ethanol (2 x 60 mL) and 1:1 cold solution of water/ethanol (30 mL). The solid was dried under high vacuum to afford tert-butyl N-diphenylmethylene-glycinate (14.9 g, 47.0 mmol, 99% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3) and mass spectrometry (LC/MS): 1H NMR δ 7.66 (2H, m), 7.47 (3H, m), 7.41 (1H, t, J=8 Hz), 7.34 (1H, t, J=8 Hz), 7.20 (2H, m), 4.13 (2H, s), 1.48 (9H, s); MS (LC/MS) m/z measured value 195.93, theoretical value 296.16 [M+H]+.

References

[1] Patent: WO2016/15159, 2016, A1. Location in patent: Page/Page column 56
[2] Patent: US9458192, 2016, B1. Location in patent: Page/Page column 44-45
[3] European Journal of Organic Chemistry, 2005, # 2, p. 317 - 325
[4] Chemical Communications, 2009, # 2, p. 168 - 170
[5] Patent: US2010/189644, 2010, A1. Location in patent: Page/Page column 23

N-(Diphenylmethylene)glycerine tert-butyl ester(81477-94-3)Related Product Information

• 4-Hydroxy-D-(-)-2-phenylglycine
• tert-Butyl glycinate
• tert-Butyl peroxybenzoate
• Tris(trimethylsilyl)phosphate
• tert-Butanol
• Diethyl phthalate
• Buprofezin
• Methyl acrylate
• 2-Butoxyethanol
• N,N-Dimethylglycine
• Butyl acetate
• tert-Butyl methacrylate
• D-2-Phenylglycine
• Glycerol
• Sodium hydroxymethylglycinate
• Butyl acrylate
• ([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER
• Ethyl N-(diphenylmethylene)glycinate