1-Aminobenzotriazole Chemical Properties

Melting point:

81-84 °C (lit.)

Boiling point:

237.24°C (rough estimate)

Density 

1.2769 (rough estimate)

refractive index 

1.7000 (estimate)

RTECS 

DM1235000

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in DMSO (up to 30mg/ml)

form 

Crystalline Powder

pka

2.09±0.30(Predicted)

color 

Yellow to beige or light brown

Water Solubility 

slightly soluble

BRN 

607843

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

CAS DataBase Reference

1614-12-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29349990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

1-Aminobenzotriazole Usage And Synthesis

Description

1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3

Chemical Properties

yellow to beige or light brown crystalline powder

Uses

1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.

Uses

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

References

1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426

1-Aminobenzotriazole(1614-12-6)Related Product Information

• 1H-Benzotriazole
• Sulfanilamide
• Phenetidine
• 5-Methyl-1H-benzotriazole
• Sulfanilic acid
• p-Anisidine
• 4,4'-Methylenedianiline
• 1,2,3-1H-Triazole
• 1-Hydroxybenzotriazole
• Aniline
• Methyl anthranilate
• 4-Amino-benzenesulfonic acid monosodium salt
• 4-Aminobenzoic acid
• 1-Hydroxybenzotriazole hydrate
• DIETHYL (BENZOTRIAZOL-1-YL)IMINOMALONATE
• 5-AMINOBENZOTRIAZOLE
• Anthranilic acid
• ITSA1