1,6-Diacetoxyhexane Chemical Properties

Melting point:

9 °C

Boiling point:

103-105°C 6mm

Density 

1.01

refractive index 

1.4280-1.4320

Flash point:

103-105°C/6mm

form 

clear liquid

color 

Colorless to Almost colorless

CAS DataBase Reference

6222-17-9(CAS DataBase Reference)

EPA Substance Registry System

1,6-Hexanediol, diacetate (6222-17-9)

Safety Information

Safety Statements 

23-24/25

RTECS 

MO2325000

TSCA 

TSCA listed

HS Code 

2915.39.4550

MSDS

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1,6-Diacetoxyhexane Usage And Synthesis

Application

1,6-Diacetoxyhexane, also known as hexanediol diacetate, can be prepared from 3-bromopropylacetate. Literature reports that it can be used to prepare the fungicide 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 2027, 1994 DOI: 10.1016/S0040-4039(00)73040-1

Synthesis

3-Bromopropyl acetate (453 mg, 2.50 mmol) was added to a solution of CoBr2 (10 mol%, 0.25 mmol, 55 mg) and manganese powder (3.8 eq, 9.5 mmol, 500 mg) in CH3CN (3 mL) at room temperature. The manganese powder was activated with a trace amount of trifluoroacetic acid (50 ??L) and stirred at room temperature for 5 min until the fumes disappeared. Pyridine (0.5 mL) was added and stirred at 50??C for 3-6 hours. Quench by adding 2MHCl (30mL) solution. The solution was extracted with Et2O or EtOAc (3x50 mL), dried over MgSO4, filtered and concentrated in vacuum. 1,6-Diacetoxyhexane was purified by rapid chromatography on silica gel.

1,6-Diacetoxyhexane(6222-17-9)Related Product Information

• 2-Methyl-2,4-pentanediol
• Cyclohexene oxide
• POLY(VINYL ACETATE)
• Acetoxyacetic acid
• Amyl acetate
• Sodium triacetoxyborohydride
• Vinyl acetate
• Methylcyclohexane
• Triacetin
• POLY(1 6-HEXAMETHYLENE ADIPATE) AVERAG&
• Hexamethylene diacrylate
• 1,6-Hexanediol
• Cyclohexane
• Benzyl acetate
• Pancuronium bromide
• Hexane
• 2,5-Hexanediol
• Silicon tetraacetate