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5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol

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5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol Basic information

Product Name:
5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
Synonyms:
  • 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
  • Moracin C
  • 5-(6-Hydroxy-2-benzofuranyl)-2-(3-methyl-2-butenyl)-1,3-benzenediol
  • 1,3-Benzenediol, 5-(6-hydroxy-2-benzofuranyl)-2-(3-methyl-2-buten-1-yl)-
  • 5-(6-hydroxy-1-benzofuran-2-yl)-2-(3-methylbut-2-enyl)benzene-1,3-diol
  • 5-(6-Hydroxybenzofuran-2-yl)-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol
CAS:
69120-06-5
MF:
C19H18O4
MW:
310.34
Mol File:
69120-06-5.mol
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5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol Chemical Properties

Boiling point:
439.4±35.0 °C(Predicted)
Density 
1.278±0.06 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
9.08±0.40(Predicted)
color 
Off-white to light yellow
InChI
InChI=1S/C19H18O4/c1-11(2)3-6-15-16(21)7-13(8-17(15)22)18-9-12-4-5-14(20)10-19(12)23-18/h3-5,7-10,20-22H,6H2,1-2H3
InChIKey
ZTGHWUWBQNCCOH-UHFFFAOYSA-N
SMILES
C1(O)=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1C/C=C(/C)\C
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5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol Usage And Synthesis

Uses

Moracin C is used as a diabetic medication and also used in other drug development. An inhibitor of Staphylococcus aureus enoyl-acyl carrier protein reductase from Morus alba leaf.

Definition

ChEBI: Moracin C is a member of benzofurans.

in vivo

Moracin C (100 mg/kg, oral gavage, mice) was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs[2].

Animal Model:Mice (PK Assay)[2]
Dosage:100 mg/kg
Administration:Oral gavage
Result:Pharmacokinetic profile of Moracin C.
Parameters Terminal half-life (min) Cmax (μg/mL) Tmax (min)CLR (mL/min/kg)
100 mg/kg2561.79150.032

target

ROS | NOS | COX | TNF-α | IL Receptor | NO | NF-kB | ERK | JNK | p38MAPK | Antifection | c-Myc

IC 50

COX-2

5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediolSupplier

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5-(6-Hydroxybenzofuran-2-yl)-2-(3-methyl-2-butenyl)-1,3-benzenediol(69120-06-5)Related Product Information