Lup-20(29)-ene-1β,3α-diol Chemical Properties

Melting point:

260-262 °C(Solv: chloroform (67-66-3); methanol (67-56-1))

Boiling point:

518.1±50.0 °C(Predicted)

Density 

1.021±0.06 g/cm3(Predicted)

pka

14.77±0.70(Predicted)

Lup-20(29)-ene-1β,3α-diol Usage And Synthesis

Uses

Glochidiol is an orally active tubulin polymerization inhibitor with an IC50 of 2.76 μM. Glochidiol shows anti-cancer activity[1].

Definition

ChEBI: 20(29)-lupene-1beta,3alpha-diol is a pentacyclic triterpenoid that is lup-20(29)-ene substituted by hydroxy groups at positions 1 and 3 respectively (the 1beta,3alpha-stereoisomer). It has been isolated from Breynia fruticosa. It has a role as a plant metabolite. It is a pentacyclic triterpenoid and a diol. It derives from a hydride of a lupane.

in vivo

References

[1] Chen H, et al. Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin. Invest New Drugs. 2021 Apr;39(2):578-586. DOI:10.1007/s10637-020-01013-1

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