GLYCYL-L-GLUTAMIC ACID Chemical Properties

Melting point:

155-158 °C (dec.)(lit.)

Boiling point:

342.66°C (rough estimate)

Density 

1.4123 (rough estimate)

refractive index 

1.4880 (estimate)

storage temp. 

-20°C

pka

3.02±0.10(Predicted)

form 

powder to crystal

color 

White to Almost white

Water Solubility 

very faint turbidity

CAS DataBase Reference

7412-78-4(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29224985

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

GLYCYL-L-GLUTAMIC ACID Usage And Synthesis

Uses

Glycyl-L-glutamic acid is a neurotrophic factor (NF) in vivo, and exerts function of maintenance of AChE content and activity. Glycyl-L-glutamic acid doesn’t act directly on AChE synthesis, and may prevent preganglionic neuronal degeneration[1][2].

Definition

ChEBI: A dipeptide formed from glycyl and L-glutamic acid residues.

References

[1] Koelle GB, et al. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Proc DOI:10.1073/pnas.82.15.5213
[2] Yourick JJ, et al. Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine. Cell Biol Toxicol. 1991 Jul;7(3):229-37. DOI:10.1007/BF00250977

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