2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties

Density 

1.551 at 21℃

vapor pressure 

0.777-1Pa at 20-25℃

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

BRN 

3993054

Stability:

Hygroscopic

InChI

InChI=1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

InChIKey

SJXPQSRCFCPWQQ-UHFFFAOYSA-N

SMILES

O=C1C=CSN1C.Cl

LogP

-0.44 at 20℃ and pH2

Surface tension

71.3mN/m at 1g/L and 20℃

CAS DataBase Reference

26172-54-3(CAS DataBase Reference)

EPA Substance Registry System

3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3)

Safety Information

Hazard Codes 

C

Risk Statements 

34-42/43

Safety Statements 

26-36/37/39-45

RIDADR 

UN 1759 8/PG 2

WGK Germany 

3

HS Code 

2934100090

MSDS

• Language:English Provider:SigmaAldrich

2-Methyl-4-isothiazolin-3-one hydrochloride Usage And Synthesis

Application

Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Uses

2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.

General Description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

storage

store at 2°C - 8°C,close container well.

2-Methyl-4-isothiazolin-3-one hydrochloride(26172-54-3)Related Product Information

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