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2-Methyl-4-isothiazolin-3-one hydrochloride

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2-Methyl-4-isothiazolin-3-one hydrochloride Basic information

Product Name:
2-Methyl-4-isothiazolin-3-one hydrochloride
Synonyms:
  • 3(2H)-Isothiazolone,2-methyl-,hydrochloride
  • MIT HYDROCHLORIDE
  • 2-Methylisothiazol-3-one hydrochloride
  • 2-METHYL-4-ISOTHIAZOLIN-3-ONE HYDROCHLORIDE
  • 2-methyl-2H-isothiazol-3-one hydrochloride
  • 2-METHYL-4-ISOTHIAZOLIN-3-ONE HCL
  • N-MethylisothiazoloneHCl
  • ISO-THIAZOLINONE(KATHON)
CAS:
26172-54-3
MF:
C4H6ClNOS
MW:
151.61
EINECS:
247-499-3
Product Categories:
  • Amines
  • Heterocycles
  • Sulfur & Selenium Compounds
Mol File:
26172-54-3.mol
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2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties

Density 
1.551 at 21℃
vapor pressure 
0.777-1Pa at 20-25℃
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
BRN 
3993054
Stability:
Hygroscopic
LogP
-0.44 at 20℃ and pH2
Surface tension
71.3mN/m at 1g/L and 20℃
CAS DataBase Reference
26172-54-3(CAS DataBase Reference)
EPA Substance Registry System
3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3)
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Safety Information

Hazard Codes 
C
Risk Statements 
34-42/43
Safety Statements 
26-36/37/39-45
RIDADR 
UN 1759 8/PG 2
WGK Germany 
3
HS Code 
2934100090

MSDS

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2-Methyl-4-isothiazolin-3-one hydrochloride Usage And Synthesis

Application

Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Uses

2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution.

General Description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone.

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

storage

store at 2°C - 8°C,close container well.

2-Methyl-4-isothiazolin-3-one hydrochlorideSupplier

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