4,5-Dichloro-2-octyl-isothiazolone Chemical Properties

Melting point:

40.0 to 44.0 °C

Boiling point:

322.6±52.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

-6.09±0.60(Predicted)

form 

Solid

color 

White to Off-White

Merck 

14,3070

Stability:

Air Sensitive

InChI

InChI=1S/C11H17Cl2NOS/c1-2-3-4-5-6-7-8-14-11(15)9(12)10(13)16-14/h2-8H2,1H3

InChIKey

PORQOHRXAJJKGK-UHFFFAOYSA-N

SMILES

S1C(Cl)=C(Cl)C(=O)N1CCCCCCCC

CAS DataBase Reference

64359-81-5(CAS DataBase Reference)

EPA Substance Registry System

4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (64359-81-5)

Safety Information

RIDADR 

3077

RTECS 

NX8157075

HS Code 

2934.10.7000

HazardClass 

9

PackingGroup 

III

Hazardous Substances Data

64359-81-5(Hazardous Substances Data)

4,5-Dichloro-2-octyl-isothiazolone Usage And Synthesis

Chemical Properties

Dichlorooctylisothiazolinone, DCOIT or DCOI, is an isothiazolinone compound. It is a white solid that melts at room temperature. It is an organic chemical that is slightly volatile and can dissolve in water. The measured K values show that DCOIT tends to move from water to octanol and has moderate to high lipophilicity.

Uses

Dichloroctylisothiazolinone is used as a broad spectrum biocide. It is used in paints especially marine coatings, decorative wood coatings and plastic industry. It is used primarily as a dry-film mildew protector for paint, coatings, paper, stains, plastics, wood, shoes, adhesives, metalworking fluids and printing inks. It is easily incorporated into water-based or solvent-based formulations.

Definition

ChEBI: 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone(DCOIT) is a 1,2-thiazole that is 1,2-thiazol-3(2H)-one substituted by chloro groups at positions 4 and 5 and an octyl group at position 2. It is used as a fungicide. It has a role as an environmental contaminant, a xenobiotic and a fungicide. It is an organochlorine compound and a member of 1,2-thiazoles.

Application

Suitable for applications in the paints and coatings, wood, and leather fields to resist corrosion and protect against mildews and algae.

Health Hazard

The chemical is referred to as 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in this assessment. Where available, data for two commercial antifouling products C-9211 HQ (32.6 % of DCOIT in xylene) and Acticide? DCOIT (97.1% purity) are used for some health end-points. The information on health hazards is primarily obtained from the comprehensive reviews from the Norwegian Environment Agency as part of its ECHA CLH proposal (ECHA, 2018) and an EU (Norway) DCOIT evaluation for the use of DCOIT as a biocide in antifouling products (EU, 2014). Unless otherwise noted, references to individual studies below are taken from these reviews.

Contact allergens

Irritant and sensitizer, Kathon? 930 caused contact dermatitis in employees of a textile fnishing factory.

Toxicology

The chemical, DCOIT is moderately absorbed through skin and moderately absorbed via oral route. It is then extensively distributed to tissues (liver, kidney, stomach and intestine) and metabolised following oral administration. In a study conducted in rats, 81–93 % of orally administered 14C-DCOIT was excreted primarily in the faeces within a 2-day period. Plasma elimination half-life of 14C-DCOIT was 16.1–19.4 hours for males and 20.5–25.0 hours for females. The highest concentration of 14C-DCOIT was found in liver, stomach, intestine and kidney. More than 80 % of the administered dose was eliminated via faeces, 11–18 % was eliminated via urine and less than 2 % of the dose was eliminated through exhaled air. DCOIT metabolised to form six metabolites in the faeces and eight metabolites in the urine. Degradation of DCOIT involves cleavage of the ring and subsequent oxidation of 7–18 % of the administrated dose to N-(n-octyl) malonamic acid (NNOMA, major metabolite), N-(n-octyl)acetamide, N-(n-octyl)oxamic acid and N-(n-octyl)-β-acetyl propionamide. The chemical undergoes subsequent biotransformation involving hydroxylation, dealkylation and acetylation (EU, 2014; ECHA, 2018).

Safety

The chemical and formulations containing the chemical applied to intact rabbit skin produced severe erythema, oedema and scar formation. The exposed areas had effects that were not reversible. Data indicates corrosive effects in the respiratory tract. While no data are available for effects in the eyes, the chemical is deemed to capable of causing severe damage. There is sufficient evidence to warrant hazard classification.

Synthesis

Add 200 g of ethyl acetate and 23.6 g (0.1 mol) of N,N'-dimethyl-3,3'-dithiodipropionamide into a 500ml four-neck flask equipped with a thermometer and a stirrer, stir and mix, and control The reaction temperature was 15° C., 1.8 g of thionyl chloride (15.1 mmol) was added to the four-neck flask, and the mixture was stirred for 10 min.21.3g (0.3mol) of chlorine gas was introduced into the reaction system, the mixture was stirred for 5h to react, and 27.1g of 4,5-Dichloro-2-octyl-isothiazolone was obtained by filtration and separation. The yield was 84.9%.

in vitro

In a bacterial gene mutation test, DCOIT was tested in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 up to a maximum concentration of 300 μg/plate with negative responses in all strains with and without metabolic activation (EU, 2014; ECHA, 2018).

in vivo

In two micronucleus assays, DCOIT was tested in CD-1 mice (5-9 mice/sex/dose) at doses up to 325 mg/kg bw/day by gavage. No genotoxicity was reported in both studies (EU, 2014; ECHA, 2018).

Precautions

1. Suitable for use in all marine paints. Can effectively kill many bacteria and mildews like penicillium notatum, basidiomycetes, aspergillus niger, fusarium, and curvularia. Can be added at any production step for use; it is recommended to adopt the concentration of 5 ~ 15% (w/w).2. Operational instruction must be strictly followed. Avoid any contact with the skin. Wear protective clothes, goggles, and rubber gloves in operation. Once any contact with the skin happens, wash the skin immediately with plenty of water and soaps; when it splashes into eyes, wash immediately with plenty of water and buffer solutions.

4,5-Dichloro-2-octyl-isothiazolone(64359-81-5)Related Product Information

• Dichloroacetonitrile
• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• 2-Methyl-4-isothiazolin-3-one
• 2-Octyl-2H-isothiazol-3-one
• 2',4'-Dichloroacetophenone
• Isothiazole
• Thiazole
• thiazol-3-one
• Isothiazolinones
• 2-Methyl-4-isothiazolin-3-one hydrochloride
• decene
• 5-Chloro-2-methyl-2H-isothiazol-3-one hydrochloride
• Octyldodecyldimethylammonium chloride
• Kathon
• OCTYL GLUCOSIDE
• 4,5-Dichloro-2-octyl-isothiazolone
• CAPRYLYL PYRROLIDONE