2,6-Difluorobenzoyl chloride Chemical Properties

Melting point:

128-132 °C(lit.)

Boiling point:

72-77 °C/13 mmHg (lit.)

Density 

1.404 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.501(lit.)

Flash point:

121 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

color 

Colorless to Light orange to Yellow

Specific Gravity

1.404

Water Solubility 

REACTS

Sensitive 

Moisture Sensitive

BRN 

639438

InChI

InChI=1S/C7H3ClF2O/c8-7(11)6-4(9)2-1-3-5(6)10/h1-3H

InChIKey

QRHUZEVERIHEPT-UHFFFAOYSA-N

SMILES

C(Cl)(=O)C1=C(F)C=CC=C1F

CAS DataBase Reference

18063-02-0(CAS DataBase Reference)

NIST Chemistry Reference

2,6-Difluorobenzoyl chloride(18063-02-0)

Safety Information

Hazard Codes 

C

Risk Statements 

36/37/38-34-10

Safety Statements 

26-36/37/39-45-28A-16

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

RTECS 

LV1763000

F 

21

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

II

HS Code 

29163990

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B

MSDS

• Language:English Provider:2,6-Difluorobenzoyl chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,6-Difluorobenzoyl chloride Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

Preservative, bactericide, furoates for perfume and flavoring, fumigant, textile processing, chemical intermediate.

Uses

2,6-Difluorobenzoyl chloride has been used in:

• the preparation of series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones
• regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridine
• Friedel-Crafts acylation reaction of toluene, anisol, thioanisol, 4-phenoxyacetophenone and N,N-diacetyl-4-phenoxyaniline

Synthesis

Step 1: In a 250 ml three-necked flask equipped with a reflux condensing device, 2,6-difluorobenzoic acid, anhydrous KF, DMF and a small amount of catalyst were added sequentially, heated to reflux, the reaction was carried out for 8 h. The reaction was cooled, filtered, and the residue of the filtrate was washed with DMF, and the filtrate and the washings were combined, and the DMF was evaporated under reduced pressure, and washed, and filtered to obtain the intermediate product of 2,6-difluorobenzoic acid, a light yellow solid.

Step 2: In a 250 ml dry three-necked flask equipped with a reflux condensing device, add 2,6-difluorobenzoic acid, thionyl chloride and a small amount of catalyst in turn, heating to reflux, the reaction is 4h, evaporate the excess thionyl chloride, to get the product 2,6-difluorobenzoyl chloride, brownish yellow liquid.

2,6-Difluorobenzoyl chloride(18063-02-0)Related Product Information

• o-Toluoyl chloride
• Thionyl chloride
• 4-Chlorobenzoyl chloride
• Choline chloride
• 4-Cyanobenzoyl chloride
• Ammonium chloride
• Calcium chloride
• p-Toluoyl chloride
• Pivaloyl chloride
• Benzoyl chloride
• 4-Methoxybenzoyl chloride
• 2-Fluorobenzoyl chloride
• 4-Fluorobenzoyl chloride
• 2,6-Difluorobenzamide
• Potassium chloride
• Polyvinyl chloride
• Sodium chloride
• 4-Nitrobenzoyl chloride