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Clinofibrate

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Clinofibrate Basic information

Product Name:
Clinofibrate
Synonyms:
  • CLINOFIBRATE (S-8527)
  • 2,2’-cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyricacid)
  • lipoclin
  • 2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl)-butanoic acid
  • CLINOFIBRATE
  • CLINOFIBRATE(FORR&DONLY)
  • 1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane
  • Butanoic acid, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-
CAS:
30299-08-2
MF:
C28H36O6
MW:
468.58
EINECS:
1312995-182-4
Product Categories:
  • API
  • Inhibitors
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
30299-08-2.mol
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Clinofibrate Chemical Properties

Melting point:
143-145°C
Boiling point:
498.6°C (rough estimate)
Density 
1.1005 (rough estimate)
refractive index 
1.4482 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Sligthly)
form 
Solid
pka
3.00±0.10(Predicted)
color 
White to Off-White
Merck 
14,2357
CAS DataBase Reference
30299-08-2(CAS DataBase Reference)
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Safety Information

RTECS 
ES8900000
HS Code 
2918.99.4700
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Clinofibrate Usage And Synthesis

Chemical Properties

White Solid

Originator

Lipocrin,Sumitomo,Japan,1981

Uses

Clinofibrate is an antilipemic, used as an anti-atherosclerosis agent.

Definition

ChEBI: Clinofibrate is an organic molecular entity.

Manufacturing Process

Into a mixture of 6.0 g of a bishydroxyphenyl derivative, and 44.0 g of methyl ethyl ketone was added 16.2 g of crushed potassium hydroxide or sodium hydroxide. Chloroform was added dropwise into the above mixture with stirring at 20°C to 80°C, and the resultant mixture was heated for 20 hours under reflux to complete the reaction. Thereafter the reaction mixture was concentrated to give a residue. Into the residue was added water. After cooling, the resultant mixture was treated with activated charcoal and acidified by diluted hydrochloric acid or sulfuric acid to give an oily substance. The oily substance was extracted by ether and the ether solution was contacted with aqueous diluted Na2CO3 solution. The separated aqueous layer was washed with ether, acidified and again extracted with ether. The obtained ester layer was dried over anhydrous sodium sulfate and concentrated to give 1.0 g of a crude product which was purified by recrystallization or chromatography, to give crystals MP 143°C to 146°C (decomp.)

Therapeutic Function

Antihyperlipoproteinemic

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