Clinofibrate
Clinofibrate Basic information
- Product Name:
- Clinofibrate
- Synonyms:
-
- CLINOFIBRATE (S-8527)
- 2,2’-cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyricacid)
- lipoclin
- 2,2'-(cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methyl)-butanoic acid
- CLINOFIBRATE
- CLINOFIBRATE(FORR&DONLY)
- 1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane
- Butanoic acid, 2,2'-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-
- CAS:
- 30299-08-2
- MF:
- C28H36O6
- MW:
- 468.58
- EINECS:
- 1312995-182-4
- Product Categories:
-
- API
- Inhibitors
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 30299-08-2.mol
Clinofibrate Chemical Properties
- Melting point:
- 143-145°C
- Boiling point:
- 498.6°C (rough estimate)
- Density
- 1.1005 (rough estimate)
- refractive index
- 1.4482 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Sligthly)
- form
- Solid
- pka
- 3.00±0.10(Predicted)
- color
- White to Off-White
- Merck
- 14,2357
- CAS DataBase Reference
- 30299-08-2(CAS DataBase Reference)
Clinofibrate Usage And Synthesis
Chemical Properties
White Solid
Originator
Lipocrin,Sumitomo,Japan,1981
Uses
Clinofibrate is an antilipemic, used as an anti-atherosclerosis agent.
Definition
ChEBI: Clinofibrate is an organic molecular entity.
Manufacturing Process
Into a mixture of 6.0 g of a bishydroxyphenyl derivative, and 44.0 g of methyl ethyl ketone was added 16.2 g of crushed potassium hydroxide or sodium hydroxide. Chloroform was added dropwise into the above mixture with stirring at 20°C to 80°C, and the resultant mixture was heated for 20 hours under reflux to complete the reaction. Thereafter the reaction mixture was concentrated to give a residue. Into the residue was added water. After cooling, the resultant mixture was treated with activated charcoal and acidified by diluted hydrochloric acid or sulfuric acid to give an oily substance. The oily substance was extracted by ether and the ether solution was contacted with aqueous diluted Na2CO3 solution. The separated aqueous layer was washed with ether, acidified and again extracted with ether. The obtained ester layer was dried over anhydrous sodium sulfate and concentrated to give 1.0 g of a crude product which was purified by recrystallization or chromatography, to give crystals MP 143°C to 146°C (decomp.)
Therapeutic Function
Antihyperlipoproteinemic
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Clinofibrate(30299-08-2)Related Product Information
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- Methyl
- 4,4'-Cyclohexylidenebisphenol
- 4-TERT-BUTYLPHENOXYACETIC ACID
- 4,4'-ISOPROPYLIDENEBIS(2-PHENOXYETHANOL)
- 2-Phenoxybutyric acid
- (S)-(+)-2-Methylbutyric acid
- Methylbutyric acid