(S)-norcolaurine Chemical Properties

Melting point:

255-256 °C

Boiling point:

522.4±50.0 °C(Predicted)

Density 

1.317±0.06 g/cm3(Predicted)

pka

9.72±0.40(Predicted)

(S)-norcolaurine Usage And Synthesis

Uses

(S)-Higenamine ((S)-Norcoclaurine), a S-enantiomer of Higenamine, is the entry compound in benzylisoquinoline alkaloid biosynthesis. (S)-Higenamine is produced by the condensation of dopamine and 4-hydroxyphenylacetaldehyde (4-HPAA) by norcoclaurine synthase (NCS)[1].

Definition

ChEBI: (S)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (S)-norcoclaurinium(1+).

References

[1] Minami H, et al. Functional analysis of norcoclaurine synthase in Coptis japonica. J Biol Chem. 2007;282(9):6274‐6282. DOI:10.1074/jbc.M608933200

(S)-norcolaurine(22672-77-1)Related Product Information

• Coclaurine
• (-)-1,2,3,4-Tetrahydro-7,8-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline
• (+)-S-N-Methylcoclaurine Hydrochloride
• 1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
• GS 389
• N-Methylcoclaurine
• 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-methoxyphenyl)methyl]-
• Demethyl-Coclaurine
• 1,2,3,4-Tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-7-isoquinolinol
• 1,2,3,4-Tetrahydro-7-methoxy-1-[(4-methoxyphenyl)methyl]-6-isoquinolinol