8-MERCAPTOGUANOSINE Chemical Properties

Melting point:

>220 °C

Density 

2.35±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly)

pka

6.15±0.20(Predicted)

form 

crystalline

color 

light yellow

Stability:

Hygroscopic

Safety Information

WGK Germany 

3

HS Code 

29389090

MSDS

• Language:English Provider:SigmaAldrich

8-MERCAPTOGUANOSINE Usage And Synthesis

Chemical Properties

Light yellow fine crystalline powder

Uses

8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll[1][2].

References

[1] Mond JJ, Hunter K, Kenny JJ, Finkelman F, Witherspoon K. 8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice. Immunopharmacology. 1989 Nov-Dec;18(3):205-12. DOI:10.1016/0162-3109(89)90018-0
[2] Feldbush TL, Ballas ZK. Lymphokine-like activity of 8-mercaptoguanosine: induction of T and B cell differentiation. J Immunol. 1985 May;134(5):3204-11. PMID:3872330

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