4-Nitro-1,3-phenylenediamine Chemical Properties

Melting point:

161°C

Boiling point:

276.04°C (rough estimate)

Density 

1.3682 (rough estimate)

vapor pressure 

0.007Pa at 25℃

refractive index 

1.6500 (estimate)

solubility 

almost transparency in hot Methanol

form 

powder to crystal

pka

0.99±0.10(Predicted)

Colour Index 

76030

color 

Yellow compound in hair dyes

Water Solubility 

<0.1 g/100 mL at 20.5 ºC

BRN 

2094904

LogP

0.55

CAS DataBase Reference

5131-58-8(CAS DataBase Reference)

EPA Substance Registry System

4-Nitro-m-phenylenediamine (5131-58-8)

Safety Information

Risk Statements 

22-36/38

Safety Statements 

26-36/37/39

RTECS 

ST2910000

TSCA 

Yes

HS Code 

2921.51.5000

Hazardous Substances Data

5131-58-8(Hazardous Substances Data)

Toxicity

LD50 orl-rat: 4500 mg/kg GTPZAB 35(2),42,91

MSDS

• Language:English Provider:3-Amino-4-nitroaniline
• Language:English Provider:ALFA

4-Nitro-1,3-phenylenediamine Usage And Synthesis

Chemical Properties

Yellow crystal powder

Uses

4-Nitro-1,3-diaminobenzene is a general chemical reagent used in the synthesis of pharmaceuticals. Used in the synthesis of potent and selective Chk-1 inhibitors in the treatment of various cancers.

Definition

ChEBI: 4-nitro-1,3-phenylenediamine is a C-nitro compound.

General Description

Orange prisms with blue luster or yellow crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Nitro-1,3-phenylenediamine is an amine/organonitrate. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for 4-Nitro-1,3-phenylenediamine are not available, but 4-Nitro-1,3-phenylenediamine is probably combustible.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic vapors of NOx.

4-Nitro-1,3-phenylenediamine(5131-58-8)Related Product Information

• 4-Nitrobenzonitrile
• 6-Aminocaproic acid
• 4-Nitrotoluene
• m-Phenylenediamine
• 4-Nitrobenzoic acid
• ALTRENOGEST
• p-Phenylenediamine
• Tris(hydroxymethyl)aminomethane
• o-Phenylenediamine
• Glycine
• Benzene-1,3-diamine dihydrochloride
• 1,3-Phenylenediamine sulfate
• 3-Aminophenol
• 1,3-Diaminoguanidine monohydrochloride
• 4-Nitrophenol
• 2,3,6-TRINITROPHENOL
• DNQX
• NITROGEN DIOXIDE