p-Acetylamino benzoic acid Chemical Properties

Melting point:

259-262 °C (dec.)(lit.)

Boiling point:

311.69°C (rough estimate)

Density 

1.2822 (rough estimate)

refractive index 

1.5600 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

pK1: 4.28 (25°C)

color 

Off-white to slightly beige

Water Solubility 

<0.1 g/100 mL at 21 ºC

BRN 

390602

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

CAS DataBase Reference

556-08-1(CAS DataBase Reference)

NIST Chemistry Reference

N-(4-Carboxyphenyl)acetic acid amide(556-08-1)

EPA Substance Registry System

Benzoic acid, 4-(acetylamino)- (556-08-1)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29242995

MSDS

• Language:English Provider:Acetylated PABA
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

p-Acetylamino benzoic acid Usage And Synthesis

Chemical Properties

white or off-white powder or crystals

Originator

4-Acetamidobenzoic acid ,ARIAC

Uses

immune stimulant (component)

Uses

Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970).

Definition

ChEBI: A amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4.

Manufacturing Process

Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0 g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture allow to stand for 6 h and stirring was continue till the solution became colorless. Hot solution was filtered and filtrate treated hydrochloric acid to slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was obtained as white precipitate, melting point 250°C.

Therapeutic Function

Antiviral

General Description

Needles or off-white powder.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Simultaneously an amide and a carboxylic acid.

Fire Hazard

Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible.

p-Acetylamino benzoic acid(556-08-1)Related Product Information

• Citric acid
• Acetyl chloride
• Polyamide
• Methyl anthranilate
• Benzocaine
• 4-Acetylbenzoic acid
• Acetyl coenzyme A sodium salt
• Fomesafen
• Acetaminophen
• 4-Aminobenzoic acid
• Phenacetin
• Acetylacetone
• Ethyl 2-(Chlorosulfonyl)acetate
• Folic acid
• 4-Dimethylaminobenzoic acid
• Rink Amide Linker
• Ascoric Acid
• p-(phenylthio)benzyl alcohol