N-METHYLISATIN Chemical Properties

Melting point:

130-133 °C (lit.)

Boiling point:

287.44°C (rough estimate)

Density 

1.314

refractive index 

1.5050 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

-2.41±0.20(Predicted)

form 

Crystalline Powder

color 

Orange to brownish

Water Solubility 

Insoluble in water.

λmax

427nm(CH2Cl2)(lit.)

BRN 

128280

CAS DataBase Reference

2058-74-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-37/38-41

Safety Statements 

26-39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

NL7939000

HazardClass 

IRRITANT

HS Code 

29337900

Toxicity

mouse,LD50,intraperitoneal,685mg/kg (685mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Pharmaceutical Chemistry Journal Vol. 15, Pg. 858, 1981.

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-METHYLISATIN Usage And Synthesis

Chemical Properties

ORANGE TO BROWNISH CRYSTALLINE POWDER

Uses

1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.

Uses

• Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
• Reactant for regioselective preparation of spirocyclic oxindole-butenolides
• Reactant for synthesis of spiro-oxindoles
• Reactant for preparation of unsymmetrical oxindoles
• Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
• Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents

Synthesis Reference(s)

Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s

General Description

The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations.

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