BUTYROLACTONE I Chemical Properties

Melting point:

74℃

Boiling point:

660.1±55.0 °C(Predicted)

Density 

1.353±0.06 g/cm3(Predicted)

RTECS 

LU0221600

storage temp. 

Store at -20°C

solubility 

Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml

form 

White solid.

pka

8.59±0.40(Predicted)

color 

White to off-white

Sensitive 

Light Sensitive

Safety Information

HS Code 

29419000

BUTYROLACTONE I Usage And Synthesis

Uses

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

Enzyme inhibitor

This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.

storage

+4°C

BUTYROLACTONE I(87414-49-1)Related Product Information

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