Flavopiridol Chemical Properties

Melting point:

52.5 °C

Boiling point:

603.6±55.0 °C(Predicted)

Density 

1.448±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic

form 

Yellow powder.

pka

6.16±0.40(Predicted)

InChIKey

BIIVYFLTOXDAOV-YVEFUNNKSA-N

SMILES

C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1

CAS DataBase Reference

146426-40-6(CAS DataBase Reference)

Safety Information

HS Code 

2934999090

Flavopiridol Usage And Synthesis

Uses

Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].

Uses

Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.

Definition

ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).

Anticancer Research

It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).

Flavopiridol(146426-40-6)Related Product Information

• CHLOROPHOSPHONAZO III
• Methyl salicylate
• METSULFURON METHYL
• Kresoxim-methyl
• Solvent Red 43
• Thiophanate-methyl
• Tetrahydro-4H-pyran-4-one
• Tribenuron methyl
• Centchroman
• Haloperidol
• Methyl
• Flavopiridol (Alvocidib) HCl
• (R)-3-Hydroxypiperidine hydrocloride
• Methyl bromide
• 4H-PYRAN-4-ONE
• 4-PIPERIDIN-4-YLPHENOL
• 2'-HYDROXY-5'-ISOPROPYLACETOPHENONE
• 4-(3-METHYLPHENYL)PIPERIDINE