Pheniramine maleate Chemical Properties

Melting point:

104-108°C

Boiling point:

489.25°C (rough estimate)

Density 

1.2233 (rough estimate)

refractive index 

1.6800 (estimate)

storage temp. 

2-8°C

solubility 

Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.

form 

Solid

color 

White

Water Solubility 

>=1 g/100 mL at 24 ºC

λmax

262nm(lit.)

Merck 

14,7235

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

132-20-7(CAS DataBase Reference)

EPA Substance Registry System

Pheniramine maleate (132-20-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

UT0175000

HS Code 

2933399090

MSDS

• Language:English Provider:Pheniramine maleate
• Language:English Provider:SigmaAldrich

Pheniramine maleate Usage And Synthesis

Chemical Properties

white powder

Originator

Trimeton Maleate, Schering ,US,1948

Uses

Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.

Definition

ChEBI: Pheniramine maleate is an organic molecular entity.

Manufacturing Process

According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the Pheniramine, BP 139°-142°C/1-2 mm. The Pheniramine maleate is produced by reaction with maleic acid.

Therapeutic Function

Antihistaminic

General Description

White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.

General Description

Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.

Fire Hazard

Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.

Biochem/physiol Actions

Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.

Side effects

Drowsiness, dizziness, dry mouth/nose/throat, headache, upset stomach, constipation, or trouble sleeping may occur. 

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